study of the combination of dexmedetomidine-propofol, dexmedetomidine and propofol for sedation

Comparative study of the combination of dexmedetomidine-propofol, dexmedetomidine and propofol for sedation during mechanical ventilation in patients hospitalized in the intensive care unit

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N54

Enrollment

Registered

2023-10-17

Start date

2023-10-23

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Need for sedation during mechanical ventilation.

Interventions

Intervention 1: Intervention group: In the first group, the loading dose of dexmedetomidine was 1 µg kg–1 h–1 within 10 minutes and then the infusion 0.1 µg kg–1h–1. Intervention 2: Intervention group

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age over 18 years and under 70 mechanical ventilation hospitalized in the intensive care unit, Glasgow coma number is less than 9.

Exclusion criteria

Exclusion criteria: Patients with contraindications to dexmedetomidine and propofol Patients with serious mental disorders and dementia People with acute infectious diseases or severe underlying diseases including liver dysfunction, cardiovascular disorders including heart block, heart rate = 60, heart failure with ejection fraction = 30%, diabetes or severe blood pressure (120/180)

Design outcomes

Primary

Measure	Time frame
Sedation rate of patients. Timepoint: At the base time (before the start of the intervention) and then every 24 hours. Method of measurement: The level of patient sedation will be evaluated using the Ramsay criterion, whose validity and reliability have been confirmed by a recent study.	—

Secondary

Measure	Time frame
Mean arterial pressure. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: barometer.;Heart Rate. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: ECG.;Arterial blood oxygen saturation. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: pulse oximeter.;Blood pressure. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: Barometer.	—

Measure

Time frame

Mean arterial pressure. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: barometer.;Heart Rate. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: ECG.;Arterial blood oxygen saturation. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: pulse oximeter.;Blood pressure. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: Barometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSayed a olfactory mousavi

Esfahan University of Medical Sciences

sayedmousavi88888@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026