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The effect of intravenous and intraperitoneal dexmedetomidine in combination with intraperitoneal bupivacaine on postoperative pain

A comparative study of the effect of adding intravenous dexmedetomidine or intraperitoneal dexmedetomidine to intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160307026950N53
Enrollment
90
Registered
2023-07-08
Start date
2023-07-23
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain.

Interventions

Intervention 1: Intervention group1: In this group of patients who dont eat anything for at least 8 hours before the operation, 20 ml of bupivacaine 0.25% with 1 µg/kg of dexmedetomidine was injected

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Candidates for laparoscopic cholecystectomy surgery ASA I & II(American society of anesthesiologist) Informed Consent to participate in the study

Exclusion criteria

Exclusion criteria: Patients with a history of allergy to the drugs used in the study (dexmedetomidine and bupivacaine) Patients with psychological problems Patients with a history of drug addiction Patients with the inability to express the intensity of pain based on the vas criterion

Design outcomes

Primary

MeasureTime frame
The severity of postoperative pain. Timepoint: In base time9before intervention), every 15 minutes in recovery,in 2, 4, 6, 12, 24 hours after surgery. Method of measurement: Visual Analogue Scale(0-10).

Secondary

MeasureTime frame
Heart Rate. Timepoint: In base time(before intervention), every 30 minutes during operation and then in recovery. Method of measurement: ECG.;Arterial blood oxygen saturation. Timepoint: In base time(before intervention), every 30 minutes during operation and then in recovery. Method of measurement: pulse oximeter.;Complication(nausea and vomiting). Timepoint: In base time(before intervention), every 30 minutes during operation and then in recovery. Method of measurement: asking.;Mean arterial pressure. Timepoint: In base time(before intervention), every 30 minutes during operation and then in recovery. Method of measurement: barometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra molaei

Esfahan University of Medical Sciences

Zmolaei78@gmail.com+98 31 3822 2532

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026