The effect of Atracurium and Cis-Atracurium injection on hemodynamic status and Neutrophil-to-Lymphocyte Ratio (NLR) during anesthesia induction

Comparison of the effect of Atracurium and Cis-Atracurium injection on hemodynamic status and Neutrophil-to-Lymphocyte Ratio (NLR) during anesthesia induction

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N48

Enrollment

Registered

2022-12-11

Start date

2022-11-06

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Change in hemodynamic status and NLR.

Interventions

Intervention 1: Intervention group A: In this group, after placing the patients on the surgical bed and connecting the monitoring and establishing two suitable intravenous lines, the first venous bloo

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 65 years old Anesthesia class I and II according to ASA criteria Candidate for anesthesia with Atracurium and Cis-Atracurium Informed consent to enter the study

Exclusion criteria

Exclusion criteria: Obesity or BMI (Body Mass Index) of more than 30 History of cardiovascular diseases and hemodynamic disorders or myocardial infarction in the last 6 months Taking psychoactive drugs, antihistamines and corticosteroids in the last week Addiction to opioid and non-opioid drugs Pregnancy and breastfeeding Having diabetes, orthostatic hypotension, bradycardia, hypokalemia, hypothyroidism, depression, long QT syndrome, asthma and allergies

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Electrocardiogram.;Blood Pressure. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Sphygmomanometer.;Oxygen saturation. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Pulse Oximeter.;Neutrophil to lymphocyte ratio. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Cell count of venous blood sample.	—

Measure

Time frame

Heart Rate. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Electrocardiogram.;Blood Pressure. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Sphygmomanometer.;Oxygen saturation. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Pulse Oximeter.;Neutrophil to lymphocyte ratio. Timepoint: before induction of anesthesia and at 3, 10, and 20 minutes after anesthesia. Method of measurement: Cell count of venous blood sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Nazem roaya

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026