Comparison of hemodynamic changes caused by induction of anesthesia with Ketamine-Propofol and Etomidate

Comparison of hemodynamic changes caused by induction of anesthesia with Ketamine-Propofol, and Etomidate in patients over 65 years old

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N46

Enrollment

Registered

2022-09-24

Start date

2022-09-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic changes in anesthesia induction.

Interventions

Intervention 1: Intervention group A: Patients in this group received 2 Micrograms/kg of fentanyl manufactured by Aburihan Pharmaceutical Company and 2mg of intravenous Midazolam manufactured by Elixi

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 65 years old Candidate for elective surgery under general anesthesia Anesthesia class I and II according to ASA criteria Informed consent to enter the study

Exclusion criteria

Exclusion criteria: History of drug, alcohol and Benzodiazepine use BMI (Body Mass Index)>30 History of seizures Adrenal gland failure High Blood Pressure Candidate for Craniotomy surgery

Design outcomes

Primary

Measure	Time frame
Blood Pressure. Timepoint: before induction of anesthesia, after induction of anesthesia, before laryngoscopy, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Sphygmomanometer.;Heart Rate. Timepoint: before induction of anesthesia, after induction of anesthesia, before laryngoscopy, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Electrocardiogram.;O2 Saturation. Timepoint: before induction of anesthesia, after induction of anesthesia, before laryngoscopy, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Pulse Oximeter.	—

Measure

Time frame

Blood Pressure. Timepoint: before induction of anesthesia, after induction of anesthesia, before laryngoscopy, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Sphygmomanometer.;Heart Rate. Timepoint: before induction of anesthesia, after induction of anesthesia, before laryngoscopy, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Electrocardiogram.;O2 Saturation. Timepoint: before induction of anesthesia, after induction of anesthesia, before laryngoscopy, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Pulse Oximeter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Soheyli Pur

Esfahan University of Medical Sciences

Msoheili8896@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026