Investigating the effect of the combination of Fentanyl-Magnesium sulfate and Fentanyl-Midazolam on hemodynamic status and sedation rate

Comparison of the effect of Fentanyl-Magnesium sulfate and Fentanyl-Midazolam combination administration on hemodynamic status and sedation rate of patients undergoing mechanical ventilation in Intensive Care Unit (ICU)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N44

Enrollment

Registered

2022-09-08

Start date

2022-09-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical ventilation in the ICU.

Interventions

Intervention 1: Intervention group A: In this group, patients are examined in terms of disease severity and hemodynamic status upon entering the ICU, and their vital signs are recorded. Then 1.5 µg/kg

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18 to 75 years Bedridden in ICU Requires mechanical ventilation for at least 12 hours Consent to participate in the study

Exclusion criteria

Exclusion criteria: Central nervous system disorders Weight more than 120 kg Use of neuromuscular blockers General or regional anesthesia allergy to the drugs used Tracheostomy patients pregnant and breastfeeding women

Design outcomes

Primary

Measure	Time frame
The amount of sedation. Timepoint: Every hour to 24 hours. Method of measurement: Richmond Anxiety-Sedation Scale.;Pain amount. Timepoint: Every hour to 24 hours. Method of measurement: Visual Analogue Scale.;Blood Pressure. Timepoint: Every hour to 24 hours. Method of measurement: Sphygmomanometer.;Heart Rate. Timepoint: Every hour to 24 hours. Method of measurement: Electrocardiogram.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Meraatian

Esfahan University of Medical Sciences

shr.mrttin@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026