Effectiveness of two compounds Propofol - Sodium thiopental and Propofol - Etomidate in Cataract surgery

Comparison of the effectiveness of two compounds Propofol - Sodium thiopental and Propofol - Etomidate on the quality of sedation and hemodynamic changes in Cataract surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N37

Enrollment

Registered

2021-10-16

Start date

2021-10-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract. Age-related cataract

Interventions

Intervention 1: Intervention group A: In this group, eligible patients, after being placed on a surgical bed and monitoring connection, first receive 300 ml per hour of normal saline for preoperative

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 60 years Grade I, II and III in ASA criteria (American Society of Anesthesia) Candidate for Cataract surgery

Exclusion criteria

Exclusion criteria: Patients with obstructive sleep apnea, mental disorder, autoimmune diseases, diabetes, nystagmus, leukemia, epilepsy and patients treated with psychiatric drugs Deafness Allergy to the drugs used Use of painkillers in the past week BMI (Body Mass Index) more than 35

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: ECG monitoring.;Sadation quality. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: RSS criteria (Ramsey sedation score).;Mean arterial blood pressure. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: Barometer.;Arterial blood oxygen saturation. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: Pulse oximeter.	—

Measure

Time frame

Heart Rate. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: ECG monitoring.;Sadation quality. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: RSS criteria (Ramsey sedation score).;Mean arterial blood pressure. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: Barometer.;Arterial blood oxygen saturation. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: Pulse oximeter.

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Secondary

Measure	Time frame
Rate of nausea and vomiting. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: Observation and asking.;Duration of anesthesia. Timepoint: From the time the first sedation drug is administered until the effects of anesthesia are over. Method of measurement: o'clock.;Duration of surgery. Timepoint: From the time the surgeon starts the cataract until the lens is done. Method of measurement: o'clock.	—

Measure

Time frame

Rate of nausea and vomiting. Timepoint: Before drug injection, 1 and 5 minutes after drug injection and then every 10 minutes until the end of recovery. Method of measurement: Observation and asking.;Duration of anesthesia. Timepoint: From the time the first sedation drug is administered until the effects of anesthesia are over. Method of measurement: o'clock.;Duration of surgery. Timepoint: From the time the surgeon starts the cataract until the lens is done. Method of measurement: o'clock.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Aria

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026