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The effect of Dexmedetomidine on nausea and vomiting in Discectomy surgery

Comparison of the effectiveness of two different doses of Dexmedetomidine on the prevention of nausea and vomiting in Discectomy under spinal anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160307026950N35
Enrollment
135
Registered
2021-09-06
Start date
2019-06-22
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting due to Discectomy under spinal anesthesia.

Interventions

Intervention 1: Intervention group D1: From the time of entering the operating room until before spinal anesthesia, 500cc of Ringer's lactate serum made in Iran was administered intravenously to patie

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 60 years Candidate for Discectomy under spinal anesthesia Grade 1 and 2 Anesthesia Based on American Society Anesthesia Criteria

Exclusion criteria

Exclusion criteria: History of cardiovascular, respiratory, neurological, endocrine, thyroid, neuromuscular diseases, dysautonomia Fever Obesity (BMI> 27) History of vasoactive drugs, MAOI and TCA History of drug use Allergy to Pethidine, Ketamine and Magnesium sulfate Pregnancy Allergy to Dexmedetomidine Taking drugs with drug interactions with Dexmedetomidine

Design outcomes

Primary

MeasureTime frame
Nausea and vomiting due to dexmedetomidine injection. Timepoint: Immediately after spinal up to 24 hours after surgery. Method of measurement: Use Visual Analogue Scale or VAS.

Secondary

MeasureTime frame
Heart Rate. Timepoint: Immediately after spinal up to 24 hours after surgery. Method of measurement: ECG monitoring.;Systolic blood pressure. Timepoint: Immediately after spinal up to 24 hours after surgery. Method of measurement: Barometer.;Diastolic blood pressure. Timepoint: Immediately after spinal up to 24 hours after surgery. Method of measurement: Barometer.;Arterial blood oxygen saturation. Timepoint: Immediately after spinal up to 24 hours after surgery. Method of measurement: Pulse oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNegar Khan ahmad

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026