The effect of Fentanyl injection and Valsalva maneuver on pain caused by Etomidate injection

Comparison of the effectiveness of Fentanyl administration and Valsalva maneuver in relieving pain caused by Etomidate injection to induce general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N33

Enrollment

Registered

2021-03-30

Start date

2021-01-04

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The pain caused by injection of Etomidate. Pain, not elsewhere classified

Interventions

Intervention 1: Intervention group A: In this group, patients first receive 2 cc of normal saline intravenously and after 3 minutes, perform the Valsalva maneuver by blowing in a plastic tube (where t

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 65 years Candidate for General Anesthesia ASA Class I and II Anesthesia Able to perform Valsalva maneuver

Exclusion criteria

Exclusion criteria: History of mental, Cardiorespiratory and chronic pain disorders Use of painkillers History of allergy to Etomidate and Fentanyl History of drug use

Design outcomes

Primary

Measure	Time frame
The amount of pain caused by Etomidate injection. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of Etomidate. Method of measurement: withdrawal response score.	—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of atomidite. Method of measurement: Manometer.;Heart Rate. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of atomidite. Method of measurement: ECG.;Blood oxygen saturation. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of atomidite. Method of measurement: Pulse Oximeter.	—

Measure

Time frame

Blood Pressure. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of atomidite. Method of measurement: Manometer.;Heart Rate. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of atomidite. Method of measurement: ECG.;Blood oxygen saturation. Timepoint: Before intervention, after intervention, immediately after injection and 1, 2, 3, 5, 10 and 15 minutes after injection of initial dose of atomidite. Method of measurement: Pulse Oximeter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolshan Mazahery

Esfahan University of Medical Sciences

www.g.mazaheri@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026