The effect of Labetalol on bleeding during lumbar spine fusion surgery

Comparison of the effect of two different doses of Labetalol on the rate of bleeding in lumbar spine fusion surgeries

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N30

Enrollment

Registered

2021-01-12

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding rate during lumbar spine fusion surgery. Ankylosing spondylitis

Interventions

Intervention 1: Intervention group A: After anesthesia, patients in this group receive Labetalol at a dose of 0.25 mg per kg body weight for 10 seconds, and then 2 mg / min as an infusion. Interventio

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 50 years Candidate for lumbar spine fusion surgery ASA Class I and II Anesthesia

Exclusion criteria

Exclusion criteria: History of any allergy to Labetalol History of heart block History of lung diseases such as asthma

Design outcomes

Primary

Measure	Time frame
The amount of bleeding during the operation. Timepoint: After surgical incision until the end of the operation. Method of measurement: Counting the number of blood gases and measuring the amount of sucked blood.	—

Secondary

Measure	Time frame
Heart Rate. Timepoint: Before surgery, during anesthesia, after anesthesia until the end of the operation, from the beginning of recovery to exit it. Method of measurement: ECG monitoring.;Blood Pressure. Timepoint: Preoperative time, anesthesia time, every 10 minutes from the start of the operation until the end of the recovery. Method of measurement: Barometer.;Percentage of arterial blood oxygen saturation. Timepoint: Before surgery, during anesthesia, after anesthesia until the end of the operation, from the beginning of recovery to exit it. Method of measurement: Pulse Oximeter.	—

Measure

Time frame

Heart Rate. Timepoint: Before surgery, during anesthesia, after anesthesia until the end of the operation, from the beginning of recovery to exit it. Method of measurement: ECG monitoring.;Blood Pressure. Timepoint: Preoperative time, anesthesia time, every 10 minutes from the start of the operation until the end of the recovery. Method of measurement: Barometer.;Percentage of arterial blood oxygen saturation. Timepoint: Before surgery, during anesthesia, after anesthesia until the end of the operation, from the beginning of recovery to exit it. Method of measurement: Pulse Oximeter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHeydar Almazy

Esfahan University of Medical Sciences

dr.haidara@hotmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026