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The effect of Valsalva maneuver and tourniquet closure on Propofol injection pain

Comparison of the effectiveness of tourniquet ligation and Valsalva maneuver in relieving pain caused by Propofol injection to induce general anesthesia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160307026950N28
Enrollment
105
Registered
2020-12-09
Start date
2020-12-21
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain from propofol injection. Pain, not elsewhere classified

Interventions

Intervention 1: Intervention group A: Patients first receive 2 ml of normal saline intravenously and after 3 minutes while the tourniquet is closed schematically, they perform the Valsalva maneuver by

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 to 65 years ASA class I and II candidate for surgery under the general anesthesia Able to perform Valsalva maneuver

Exclusion criteria

Exclusion criteria: Having respiratory problems Drug addiction and stimulants Allergy to Propofol Having underlying diseases such as diabetes, cardiovascular problems, liver disorders Existence of chronic pain syndromes and thrombophlebitis Take any analgesic and sedative before anesthesia

Design outcomes

Primary

MeasureTime frame
Pain from propofol injection. Timepoint: 20 seconds after propofol injection. Method of measurement: withdrawal response score questionnaire.

Secondary

MeasureTime frame
Blood Pressure. Timepoint: Before intervention, after intervention, after injection of propofol every 1 to 3 minutes, 5 minutes after induction of anesthesia, 10 minutes after induction of anesthesia. Method of measurement: Barometer.;Heart Rate. Timepoint: Before intervention, after intervention, after injection of propofol every 1 to 3 minutes, 5 minutes after induction of anesthesia, 10 minutes after induction of anesthesia. Method of measurement: ECG monitoring.;Arterial blood oxygen saturation. Timepoint: Before intervention, after intervention, after injection of propofol every 1 to 3 minutes, 5 minutes after induction of anesthesia, 10 minutes after induction of anesthesia. Method of measurement: Pulse Oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Sajad

Esfahan University of Medical Sciences

Zahrasajad1995@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026