Effect of Dexamethasone on Nausea and Vomitting after cholecystectomy

Comparison of the efficacy of Intraperitoneal Dexamethasone with intravenous Dexamethasone on Nausea and Vomiting after Laparoscopic Cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N25

Enrollment

Registered

2020-09-20

Start date

2020-09-22

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy. K00-K93

Interventions

Intervention 1: Intervention group A: Patients receive 2cc intrapritoneal Normal saline and 8mg intravenous Dexamethasone in base of Gallbladder after removing last clamp and exiting laparoscope. In

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age above 18 years Candidate for laparoscopic Cholecystectomy Physical Situation ASAP and ASA2 Agreement on Participation in Study

Exclusion criteria

Exclusion criteria: Pregnancy Allergy and Reaction to Corticosteroids Using corticosteroids before Surgery Existing of Nausea and Vomitting before Surgery

Design outcomes

Primary

Measure	Time frame
Nausea. Timepoint: After entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.;Vomitting. Timepoint: After entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.;Systolic blood pressure. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Diastolic blood pressure. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Heart rate. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: ECG Monitoring.;Oxygen saturation. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Pulse oximeter.;Pain. Timepoint: After entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: VAS score system.;Patients satisfaction. Timepoint: First 24 hour after surgery. Method of measurement: Likert scale system.	—

Measure

Time frame

Nausea. Timepoint: After entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.;Vomitting. Timepoint: After entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.;Systolic blood pressure. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Diastolic blood pressure. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Heart rate. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: ECG Monitoring.;Oxygen saturation. Timepoint: Before Anesthesia, After Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Pulse oximeter.;Pain. Timepoint: After entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: VAS score system.;Patients satisfaction. Timepoint: First 24 hour after surgery. Method of measurement: Likert scale system.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Arabzadeh

Esfahan University of Medical Sciences

alirezaarabzadeh994@gmail.com+98 31 3669 1460

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026