Effect of Ephedrine and Ketamine on rapid sequence intubation using Priming Dose of Cis-Atracurium

Comparison of the effectiveness of low-dose Ephedrine and Ketamine injections on rapid sequence intubation using Priming Dose of Cis-Atracurium in patients under general anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N24

Enrollment

128

Registered

2020-09-19

Start date

2020-06-21

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rapid sequence intubation.

Interventions

Intervention 1: Intervention group E: each patient is injected with Ephedrine 70 Mcr gr/kg before induction. Intervention 2: Intervention group: K: That each patient is injected with 0.5 mg/kg Ketamin

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: All patients are candidates for elective surgery under general anesthesia Age 18 to 65 years ASA Class I and II Anesthesia Patient consent to study

Exclusion criteria

Exclusion criteria: History of moderate to severe allergy

Design outcomes

Primary

Measure	Time frame
Reaction to laryngoscopy. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.;Position of vocal cords. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.;Diaphragm muscle movement. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.;Opening the patient's mouth. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.	—

Measure

Time frame

Reaction to laryngoscopy. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.;Position of vocal cords. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.;Diaphragm muscle movement. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.;Opening the patient's mouth. Timepoint: 60 seconds after Cis Atracurium injection. Method of measurement: Cooper Scoring Criterion.

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Secondary

Measure	Time frame
Heart rate. Timepoint: Before induction of anesthesia, after induction of anesthesia, and every 15 minutes until the end of anesthesia. Method of measurement: ECG monitoring.;Oxygen saturation. Timepoint: Before induction of anesthesia, after induction of anesthesia, and every 15 minutes until the end of anesthesia. Method of measurement: Pulse oximeter.;Blood Pressure. Timepoint: Before induction of anesthesia, after induction of anesthesia, and every 15 minutes until the end of anesthesia. Method of measurement: Non-invasive blood pressure measurement.;Drug side effects. Timepoint: From the end of anesthesia to the end of recovery. Method of measurement: Observe and ask the patient.;Recovery time. Timepoint: From the end of anesthesia to the exit of recovery. Method of measurement: Timer.	—

Measure

Time frame

Heart rate. Timepoint: Before induction of anesthesia, after induction of anesthesia, and every 15 minutes until the end of anesthesia. Method of measurement: ECG monitoring.;Oxygen saturation. Timepoint: Before induction of anesthesia, after induction of anesthesia, and every 15 minutes until the end of anesthesia. Method of measurement: Pulse oximeter.;Blood Pressure. Timepoint: Before induction of anesthesia, after induction of anesthesia, and every 15 minutes until the end of anesthesia. Method of measurement: Non-invasive blood pressure measurement.;Drug side effects. Timepoint: From the end of anesthesia to the end of recovery. Method of measurement: Observe and ask the patient.;Recovery time. Timepoint: From the end of anesthesia to the exit of recovery. Method of measurement: Timer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPouyan Nadery Afshar

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026