The effect of the combination of Ketamine and Midazolam as well as a combination of ketamine and dexmedetomidine in Electroshock therapy

Comparison of the effect of low dose Ketamine and Midazolam injection with low dose Ketamine and Dexmedetomidine on changes in heart rate and blood pressure in Electroconvulsive therapy

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N23

Enrollment

Registered

2020-09-14

Start date

2020-09-22

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ElectroConvulsive Therapy.

Interventions

Intervention 1: Intervention group A: The patient will receive 0.1 mg / kg of Ketamine and 0.04 mg / kg of Midazolam. Intervention 2: Intervention group B: The patient will receive 0.1 mg per kg bodyw

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Candidate patients for Electroconvulsive Therapy Age 18 to 65 Patient consent to study

Exclusion criteria

Exclusion criteria: History of drug allergy History of cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: Before drug injection, after drug injection, after shock termination, 5 and 10 minutes after end of seizure. Method of measurement: ECG monitoring.;Blood Pressure. Timepoint: Before drug injection, after drug injection, after shock termination, 5 and 10 minutes after end of seizure. Method of measurement: Non-invasive blood pressure measurement.;Oxygen Saturation. Timepoint: Before drug injection, after drug injection, after shock termination, 5 and 10 minutes after end of seizure. Method of measurement: Pulse Oxymeter.	—

Measure

Time frame

Heart Rate. Timepoint: Before drug injection, after drug injection, after shock termination, 5 and 10 minutes after end of seizure. Method of measurement: ECG monitoring.;Blood Pressure. Timepoint: Before drug injection, after drug injection, after shock termination, 5 and 10 minutes after end of seizure. Method of measurement: Non-invasive blood pressure measurement.;Oxygen Saturation. Timepoint: Before drug injection, after drug injection, after shock termination, 5 and 10 minutes after end of seizure. Method of measurement: Pulse Oxymeter.

—

Secondary

Measure	Time frame
Duration of seizures. Timepoint: From the beginning to the end of the seizure. Method of measurement: Chronometer.;Complications after anesthesia. Timepoint: From the time of drug discontinuation to the end of recovery. Method of measurement: View patient status.;Recovery time. Timepoint: From stopping the drug to full consciousness. Method of measurement: Chronometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Manian

Esfahan University of Medical Sciences

Zahra.maniann@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026