The effect of pre-operative administration of Dexmedetomidine on pulse rate and blood pressure following the administration of Ketamine for electroconvulsive therapy

Comparison of pre-operative administration of Dexmedetomidine on pulse rate and blood pressure with placebo following the administration of Ketamine for electroconvulsive therapy of pediatric

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N10

Enrollment

Registered

2019-04-24

Start date

2018-03-21

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Blood pressure. Condition 2: Heart rate. Elevated blood-pressure reading, without diagnosis of hypertension Tachycardia, unspecified

Interventions

Intervention 1: Intervention group : Initially, personal consent is obtained from the parents of patients. Then the patient is placed on the operating bed and standard monitoring devices including pul

Eligibility

Sex/Gender

All

Age

6 Years to 25 Years

Inclusion criteria

Inclusion criteria: Patients candidate receiving electroconvulsive therapy Patients older than 6 yeras old and younger than 25 years old Patients with American society of anesthesiology physical status class 1,2 (ASAI,II)

Exclusion criteria

Exclusion criteria: Addiction to drugs and alcohol History of cardio-pulmonary diseases History of consumption of Beta blockers and narcotics and high blood pressure drugs Drug allergy

Design outcomes

Primary

Measure	Time frame
Heart rate changes. Timepoint: Before the intervention, 1 , 5, 10 minutes after end of seizure and then the discharge time of recovery. Method of measurement: Heart monitoring.;Mean arterial blood pressure. Timepoint: Before the intervention, 1 , 5, 10 minutes after end of seizure and then the discharge time of recovery. Method of measurement: Non invasive blood pressure monitor.;Duration of seizure. Timepoint: After intervention. Method of measurement: In seconds using a chornometer.;Oxygen saturation. Timepoint: Before the intervention, 1,5,10 minutes after end of seizure and then the discharge time of recovery. Method of measurement: Percent with pulse oximeter.;Recovery time. Timepoint: From the end of seizure to full consciousness. Method of measurement: Minute with using a chronometer.	—

Measure

Time frame

Heart rate changes. Timepoint: Before the intervention, 1 , 5, 10 minutes after end of seizure and then the discharge time of recovery. Method of measurement: Heart monitoring.;Mean arterial blood pressure. Timepoint: Before the intervention, 1 , 5, 10 minutes after end of seizure and then the discharge time of recovery. Method of measurement: Non invasive blood pressure monitor.;Duration of seizure. Timepoint: After intervention. Method of measurement: In seconds using a chornometer.;Oxygen saturation. Timepoint: Before the intervention, 1,5,10 minutes after end of seizure and then the discharge time of recovery. Method of measurement: Percent with pulse oximeter.;Recovery time. Timepoint: From the end of seizure to full consciousness. Method of measurement: Minute with using a chronometer.

—

Secondary

Measure	Time frame
Nausea and Vomiting. Timepoint: After end of the siezure. Method of measurement: Questionnaire.;Laryngospasm. Timepoint: After end of the siezure. Method of measurement: Evaluation of respiration and oxygen saturation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Babhadiashar

Esfahan University of Medical Sciences

mrzybha@gmail.com+98 31 3236 7487

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026