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Evaluate and compare the analgesic effect of morphine combined with different low dose of ketamine , as compared to morphine in trauma patients admitted to the emergency department with acute , moderate to severe pain.

Evaluate and compare the analgesic effect of morphine combined with different low dose of ketamine , as compared to morphine in trauma patients admitted to the emergency department with acute , moderate to severe pain.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016030626927N1
Enrollment
180
Registered
2016-06-09
Start date
2015-12-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: UPPER limb injury. Condition 2: injuries of upper limb, level unspecified. Condition 3: Other injuries of lower limb, level unspecified. Condition 4: Fracture of lower limb, level unspecified. Fracture of upper limb, level unspecified Other injuries of upper limb, level unspecified Other injuries of lower limb, level unspecified Fracture of lower limb, level unspecified

Interventions

Intervention 1: Injection of 0.1mg / kg of morphine with a few ml of distilled water in separate syringes in the control group. Intervention 2: Injection of 0.1mg / kg morphine with low doses of keta
Treatment - Drugs
Injection of 0.1mg / kg of morphine with a few ml of distilled water in separate syringes in the control group
Injection of 0.1mg / kg morphine with low doses of ketamine in the intervention group

Sponsors

Vice President of Research IN Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: LIMB TRAUMA;PAIN SCORE>5 ;AGE between 18-65 ; no Underlying disease ; No history of drug allergy ; No history of addiction; Exclusion criteria: Lack of coperation or consent of the patient during the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pulse rate. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: counting.;Respiratory rate. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: counting.;Pain. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: vissual scale assessment.;Blood pressure. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: manometer.;O2 saturation. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: pulse oxymetry.—

Secondary

MeasureTime frame
Nausea. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Vomitting. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Apnea. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Hypoventiation. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Aspiration. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Confusion. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Dysphpria. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Drug reaction. Timepoint: To 3 hours after injection. Method of measurement: patient warning.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Baghaei

Iran University of Medical Sciences

dr.baghaei.m@gmail.com+98 21 8899 5017

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026