Skip to content

Studying the effect of yarrow extract on menstrual pain in patients with endometriosis

Studying the effect of yarrow extract (Achillea millefolium) compared to placebo on pain and dysmenorrhea in patients with endometriosis (Phase 2 clinical trial)

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160306026938N21
Enrollment
70
Registered
2025-04-16
Start date
2025-05-05
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis. Endometriosis

Interventions

Intervention 1: Intervention group: They receive dienogest tablets (which are a common treatment for endometriosis) 2 mg daily and yarrow medicine (containing 150 mg of dry hydroalcoholic extract) thr

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Women with secondary dysmenorrhea due to endometriosis Age of 18 to 50 years Normal reproductive function in terms of menstrual frequency and duration, and no amenorrhea in the last trimester.

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding Use of hormonal drugs in the last three months Use of drugs that may interfere with the use of our drugs Including anticonvulsants and corticosteroids, narcotics and sleeping pills, antacids such as cimetidine and famotidine and omeprazole, antihypertensive drugs Previous allergy to fruits of the Compositae family (such as chicory, sunflower, yarrow or chamomile) Other causes for dysmenorrhea, including uterine infection, etc. Needing endometriosis surgery Concomitant disease (including chronic pulmonary, hepatic and renal disease, asthma, diabetes, thyroid, mental)

Design outcomes

Primary

MeasureTime frame
Dysmenorrhea rate according to the Visual Analogue Scale. Timepoint: At the beginning of the study and monthly during menstruation during the trial. Method of measurement: Visual Analogue Scale.;Chronic Pelvic Pain. Timepoint: At the beginning of the study and monthly during the trial. Method of measurement: Visual Analogue Scale.;Dyspareunia. Timepoint: At the beginning of the study and monthly during the trial. Method of measurement: Visual Analogue Scale.

Secondary

MeasureTime frame
Size of endometriosis lesions. Timepoint: At the beginning of the trial and at the end of the trial after three months. Method of measurement: Abdominal/vaginal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Vazirian

Tehran University of Medical Sciences

vazirian_m@tums.ac.ir+98 21 6412 1223

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026