Evaluation of the Sambucus ebulus topical gel effect in reducing knee osteoarthritis

Evaluation of a stable gel formulation of Sambucus ebulus leaf extract in reducing knee osteoarthritis pain (mild and moderate) in a clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160306026938N16

Enrollment

Registered

2023-02-25

Start date

2023-05-31

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Primary generalized (osteo)arthritis

Interventions

Intervention 1: Intervention group: Sambucus gel will applied topically in the pain area, three times a day, for one month, in the amount of two index finger joints and gently massaged for 30 seconds.

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: Diagnosis of mild to moderate osteoarthritis (grade 1 to 3) by a specialist doctor by X-Ray or, if needed, MRI Age range: 35-75 years old

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Having acute diseases (infectious or non-infectious) Suffering from incurable chronic diseases such as: cancer, types of epilepsy, MS, widespread skin diseases Having other types of joint or bone diseases

Design outcomes

Primary

Measure	Time frame
The amount of pain in the knees based on scoring from zero to ten based on Visual Analogue Scale). Timepoint: At the beginning of the study (before the start of the intervention), every two weeks for three months after consuming the gel. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Vazirian

Tehran University of Medical Sciences

Vazirian_m@tums.ac.ir+98 21 6648 2609

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026