The effect of a probiotic supplementation versus no treatment on level of salivary TNF-a in patients with type 2 diabetes

The effect of a probiotic supplementation versus no treatment on level of salivary TNF-a in patients with type 2 diabetes: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201603029014N93

Enrollment

Registered

2016-04-03

Start date

2016-04-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Non-insulin-dependent diabetes mellitus

Interventions

Intervention 1: Routine treatment plus Familact capsule 500 mg one a day for 8 weeks. Intervention 2: Routine treatment only.

Treatment - Drugs

Routine treatment plus Familact capsule 500 mg one a day for 8 weeks

Routine treatment only

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) having type 2 diabetes; (b) body mass index equal to or greater than 25. Exclusion criteria: (a) using insulin, corticosteroids, immunosuppressive drugs, or non-steroidal anti-inflammatory drugs; (b) smoking; (c) thyroid dysfunction; (d) cardiovascular diseases or renal failure; (e) pregnancy or breastfeeding; (f) using any kind of probiotic products in the past two months.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Measuring the level of TNF-a. Timepoint: in fourth and eighth weeks after treatment. Method of measurement: using Bendcrmedsystem kit.	—

Secondary

Measure	Time frame
Nothing. Timepoint: Nothing. Method of measurement: Nothing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Mardani

School of Dentistry

maryammardani292@yahoo.com+98 81 3838 1086

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026