The effect of vitamin D on urosepsis

Randomized clinical trial comparison of vitamin D and placebo in urosepsis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016030223552N7

Enrollment

100

Registered

2016-10-15

Start date

2015-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis. Sepsis due to other Gram-negative organisms

Interventions

Intervention 1: Intervention group : These patients receive 300000 IU vitamin D ( institut Pasteur.Tehran .Iran ) ,with 1 cc volume, Intramuscular. Intervention 2: Control group : These patients

Treatment - Drugs

Placebo

Intervention group : These patients receive 300000 IU vitamin D ( institut Pasteur.Tehran .Iran ) ,with 1 cc volume, Intramuscular

Control group : These patients receive 1 ml intramuscular normal saline as placebo.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 18 to 70 years old; Sepsis diagnosis with urinary tract infection; Patients satisfaction Exclusion criteria: Calcium level greater than or equal to 10 mg/dl; Vitamin D intake during 7 days ago; History of parathyroid diseases; Metabolic bone disease; Sarcoidosis; End stage renal disease (ESRD); Impending death; Pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
White blood cell. Timepoint: every 24 hours to 72 hours. Method of measurement: Number per microliter.;Temperature. Timepoint: every 6 hours to 72 hours. Method of measurement: Thermometer.;ESR. Timepoint: Every 24 hours to 72 hours. Method of measurement: mm per hour.;Creatinine. Timepoint: Every 24 hours to 72 hours. Method of measurement: mg /dl.;CRP. Timepoint: Every 24 hours to 72 hours. Method of measurement: mg/dl.	—

Measure

Time frame

White blood cell. Timepoint: every 24 hours to 72 hours. Method of measurement: Number per microliter.;Temperature. Timepoint: every 6 hours to 72 hours. Method of measurement: Thermometer.;ESR. Timepoint: Every 24 hours to 72 hours. Method of measurement: mm per hour.;Creatinine. Timepoint: Every 24 hours to 72 hours. Method of measurement: mg /dl.;CRP. Timepoint: Every 24 hours to 72 hours. Method of measurement: mg/dl.

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Secondary

Measure	Time frame
Systolic blood pressure. Timepoint: Every 6 hours to 72 hours. Method of measurement: Sphygmomanometer.;Diastolic blood pressure. Timepoint: Every 6 hours to 72 hours. Method of measurement: Sphygmomanometer.;Heart rate. Timepoint: Every 6 hours to 72 hours. Method of measurement: Pulse per minute.;Respiratory rate. Timepoint: Every 6 hours to 72 hours. Method of measurement: Respitation per minute.;Blood urea nitrogen ( BUN ). Timepoint: Every 6 hours to 72 hours. Method of measurement: mg / dl.;Calcium. Timepoint: At baseline and 72 hour after injection. Method of measurement: mg / dl.;Phosphorus. Timepoint: At baseline and 72 hour after injection. Method of measurement: mg / dl.;Vitamin D. Timepoint: At baseline and 72 hour after injection. Method of measurement: mg / dl.;Uric acid. Timepoint: Every 24 hours to 72 hours. Method of measurement: mg/dl.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Every 6 hours to 72 hours. Method of measurement: Sphygmomanometer.;Diastolic blood pressure. Timepoint: Every 6 hours to 72 hours. Method of measurement: Sphygmomanometer.;Heart rate. Timepoint: Every 6 hours to 72 hours. Method of measurement: Pulse per minute.;Respiratory rate. Timepoint: Every 6 hours to 72 hours. Method of measurement: Respitation per minute.;Blood urea nitrogen ( BUN ). Timepoint: Every 6 hours to 72 hours. Method of measurement: mg / dl.;Calcium. Timepoint: At baseline and 72 hour after injection. Method of measurement: mg / dl.;Phosphorus. Timepoint: At baseline and 72 hour after injection. Method of measurement: mg / dl.;Vitamin D. Timepoint: At baseline and 72 hour after injection. Method of measurement: mg / dl.;Uric acid. Timepoint: Every 24 hours to 72 hours. Method of measurement: mg/dl.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Abolfazl Jokar

Vali-e-Asr hospital

dr.a.jokar@gmail.com+98 86332222003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026