Evaluating the effects of using of dexamethasone and chlorpheniramine in the prevention of postoperative nausea and pain in patients undergoing Laparoscopic Gallbladder Surgery

Evaluating the effects of using a single dose of dexamethasone and chlorpheniramine alone and together in the prevention of postoperative nausea and pain in patients undergoing laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016030126853N1

Enrollment

100

Registered

2016-05-01

Start date

2015-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea & Vomiting , Following laparoscopic cholecystectomy. Vomiting following gastrointestinal surgery

Interventions

Intervention 1: Group 1 received 8 mg of dexamethasone(DarouPakhsh) 30 minutes before the operation. Intervention 2: Group 2 received a vial of chlorpheniramine (Alborz Darou) 30 minutes before the op

Prevention

Treatment - Other

Group 1 received 8 mg of dexamethasone(DarouPakhsh) 30 minutes before the operation.

Group 2 received a vial of chlorpheniramine (Alborz Darou) 30 minutes before the operation.

Group 3 received a vial of chlorpheniramine(Alborz Darou) along with 8 mag of dexamethasone(DarouPakhsh) 30 minutes before the operation.

group 4 (control group ) received no drugs.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Undergoing elective surgery laparoscopic cholecystectomy. Exclusion criteria: Opium addiction; liver disorders; tuberclosis or latent tuberclosis; Hypothyroidism; using Steroids, Antihistamines or Digoxin, Oral contraceptive pill and Amphotericin; diabetes melitus; fungal infections; hyper tension; morbid obesity; the use of antiemetic agents during 24 hrs before surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Every 2 to 12 hours after the removal of tracheal tube. Method of measurement: based on the visual analogue scales (VAS).	—

Secondary

Measure	Time frame
Nausea. Timepoint: Every 2 to 12 hours after the removal of tracheal tube. Method of measurement: Based on observation and scoring criteria.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hoda Hekmat

Velayat educational and treatment center

hodaaa523@yahoo.com+98 28 3376 0620

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026