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Comparing Therapeutic effects of combination of high volume normal saline and salbutamol nebulizer with combination of hypertonic saline 3% and salbutamol nebulizer in bronchiolitis treatment

Evaluation of efficacy of combination of nebulized salbutamol with high concentration of saline (normal saline 0/9%, hypertonic saline 3%) in bronchiolitis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016022826809N1
Enrollment
180
Registered
2016-04-23
Start date
2014-09-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis. Other acute lower respiratory infections

Interventions

Intervention 1: First group: receive 5 ml hypertonic saline 3% and 0.15 mg/kg nebulized salbutamol. Intervention 2: Second group: receive 5 ml normal saline 0.9% and 0.15 mg/kg nebulized salbutamol. I
Treatment - Drugs
First group: receive 5 ml hypertonic saline 3% and 0.15 mg/kg nebulized salbutamol.
Second group: receive 5 ml normal saline 0.9% and 0.15 mg/kg nebulized salbutamol.
Third group: receive 10 ml normal saline 0.9% and 0.15 mg/kg nebulized salbutamol.

Sponsors

Vice chancellor for research,Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Months to 2 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age less than 2 year old; history of recent upper respiratory viral infection which caused wheeze and crackle in auscultation; CBSS 4-8 in admit. Exclusion criteria: age less than 1 month or more than 2 years old; history of recurrent attack of wheeze; sever neurological disorder; consolidation in Chest x ray; immune deficiency; congenital heart disease; history of premature (gestational age less than 34 weeks); birth weight less than 2500 gr; saturation of oxygen less than 85% in room; CBSS less than 4 or more than 8; unstable hemodynamic (heart rate more than 200 per minute, blood pressure 2 standard deviation more or less than normal range for age and sex, respiratory rate more than 70 per minute).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Respiratory rate. Timepoint: Pretreatment and each 30 minute up to 3 times after the begining of treatment. Method of measurement: Counting respiratory rate in 1 minute.;O2 saturation. Timepoint: Pretreatment and each 30 minute up to 3 times after the begining of treatment. Method of measurement: Pulse oximetery.;Heart rate. Timepoint: Pretreatment and each 30 minute up to 3 times after the begining of treatment. Method of measurement: Counting heart rate in 1 minute.;Intercostal retraction. Timepoint: Pretreatment and each 30 minute up to 3 times after the begining of treatment. Method of measurement: Physical exam and score of CBSS (0,1,2,3).;Dyspnea. Timepoint: Pretreatment and each 30 minute up to 3 times after the begining of treatment. Method of measurement: Physical exam and score of CBSS (0,1,2,3).;Wheezing. Timepoint: Pretreatment and each 30 minute up to 3 times after the begining of treatment. Method of measurement: Physical exam and score of CBSS (0,1,2,3).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFariba Goodarzi

Zahedan Medical University

F.goodarzi@zaums.ac.ir+98 54 3329 5580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026