Effect of magnesium sulfate on reduction of need to opium after lower extremity fractures surgery operation

Effect of magnesium sulfate on reduction of need to opium, prolongation of block duration and pain after lower extremity fractures surgery operation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016022825676N3

Enrollment

Registered

2016-05-07

Start date

2015-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lower limb fracture. Fracture of lower limb, level unspecified

Interventions

Intervention 1: In magnesium group (M) after spinal anesthesia, 15minute later 50mg/kg from 20% magnesium solution in 250 cc Normal saline in 20 minutes administered. Intervention 2: Control group (c

Treatment - Drugs

Placebo

In magnesium group (M) after spinal anesthesia, 15minute later 50mg/kg from 20% magnesium solution in 250 cc Normal saline in 20 minutes administered.

Control group (c), after spinal anesthesia 15 minuits later from block received only 250cc normal saline.

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 45_75 years old; ASA 1 & 2; undergoing elective surgery of lower extremity fractures ; spinal anesthesia; pleasure in entrance to study. Exclusion criteria: diabetes; hypertension; myopathy; opium or alcohol addiction; Advanced heart disease and heart block inside; kidney & liver disorders; magnesium supplement & calcium channel blocker receivers; pregnant patients & neurologic disorders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Immediately after operation and 4, 8, 12, 24 & 48 Hours after. Method of measurement: Score of pain in Visual analog scale (VAS).;Amount of analgesic consumption. Timepoint: 24 & 48 hours after operation. Method of measurement: Patient control analgesia poump.;Duration of spinal block. Timepoint: Since start of spinal anesthesia till return of sensory motor block after operation. Method of measurement: Objective.	—

Measure

Time frame

Pain. Timepoint: Immediately after operation and 4, 8, 12, 24 & 48 Hours after. Method of measurement: Score of pain in Visual analog scale (VAS).;Amount of analgesic consumption. Timepoint: 24 & 48 hours after operation. Method of measurement: Patient control analgesia poump.;Duration of spinal block. Timepoint: Since start of spinal anesthesia till return of sensory motor block after operation. Method of measurement: Objective.

—

Secondary

Measure	Time frame
Quality of sleep. Timepoint: The first night after operation. Method of measurement: Score of sleep in Visual analog scale (VAS).;Patients satisfaction of pain control. Timepoint: Immediately after operation and 4, 8, 12, 24 & 48 Hours after. Method of measurement: Score of satisfaction based on Visual analog scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Parastu Izadpanahi

Qazvin University of Medical Sciences

vcrc92@yahoo.com+98 28 3376 0620

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026