The effect of magnesium sulfate on hemodynamic changes in patients undergoing laparoscopic cholecystectomy

Evaluation the effect of magnesium sulfate in comparison with lidocaine on hemodynamic changes after endotracheal intubation and carbon dioxide insufflation in patients who undergo laparoscopic cholecystectomy: a clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016022716612N6

Enrollment

Registered

2016-09-09

Start date

2016-03-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic cholecystectomy. Cholelithiasis, Cholecystitis, Other diseases of gallbladder

Interventions

Intervention 1: Intervention group: Magnesium sulfate 30 mg/kg which was diluted to 20 ml by adding distilled water. Medications were injected immediately after venipuncture. Intervention 2: Control g

Treatment - Drugs

Intervention group: Magnesium sulfate 30 mg/kg which was diluted to 20 ml by adding distilled water. Medications were injected immediately after venipuncture.

Control group: Intravenous lidocaine 1.5 mg/kg which was diluted to 20 ml by adding distilled water. Medications were injected immediately after venipuncture.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients of both genders who referred to Imam Khomeini Hospital Of Ardabil for laparoscopic cholecystectomy (age range: 18-70 years). Exclusion criteria: Allergy to magnesium sulfate? hypermagnesemia? hypertension? morbid obesity? and severe hepatic, renal, endocrine, and cardiac dysfunction

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood pressure changes. Timepoint: Basic vital signs, before laryngoscopy, after endotracheal intubation (in 1-5 minute intervals), before carbon dioxide insufflation, 5 minutes after carbon dioxide insufflation, 15 minutes after carbon dioxide insufflation, 30 minutes after carbon dioxide insufflation. Method of measurement: In mmHg, with barometer.;Heart rate changes. Timepoint: Basic vital signs, before laryngoscopy, after endotracheal intubation (in 1-5 minute intervals), before carbon dioxide insufflation, 5 minutes after carbon dioxide insufflation, 15 minutes after carbon dioxide insufflation, 30 minutes after carbon dioxide insufflation. Method of measurement: Counting heart beats.	—

Measure

Time frame

Blood pressure changes. Timepoint: Basic vital signs, before laryngoscopy, after endotracheal intubation (in 1-5 minute intervals), before carbon dioxide insufflation, 5 minutes after carbon dioxide insufflation, 15 minutes after carbon dioxide insufflation, 30 minutes after carbon dioxide insufflation. Method of measurement: In mmHg, with barometer.;Heart rate changes. Timepoint: Basic vital signs, before laryngoscopy, after endotracheal intubation (in 1-5 minute intervals), before carbon dioxide insufflation, 5 minutes after carbon dioxide insufflation, 15 minutes after carbon dioxide insufflation, 30 minutes after carbon dioxide insufflation. Method of measurement: Counting heart beats.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Masood Entezari

Ardabil University Of Medical Sciences

M.entezari @arums.ac.ir+98 45 3325 1688

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026