prolonged pregnancy. Prolonged pregnancy
Conditions
Interventions
Intervention 1: 25 mg vaginal misoprostol will be administered and will be followed by 40 mg vaginal isosorbide mononitrate. Intervention 2: 25 mg vaginal misoprostol will be administered and will be
Treatment - Drugs
Placebo
25 mg vaginal misoprostol will be administered and will be followed by 40 mg vaginal isosorbide mononitrate
25 mg vaginal misoprostol will be administered and will be followed by vaginal placebo
Sponsors
Vice Chancellor for Research, Mashhad university of medical sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: The inclusion criteria are first pregnancies aged more than 41 weeks based on the sonography; with single; normal fetus; and cephalic presentation with no complication and before induction bishop score less than 6. Exclusion criteria include known allergy for prostaglandins or mifepristone; any contraindication for induction (such as uterine scar); contraindications for mifepristone administration (like adrenal, renal or liver disease); major cephalopelvic disproportion; abnormal stress test; vaginal bleeding and sever oligohydramnios.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fetal heart rate. Timepoint: each 30 minutes. Method of measurement: quantitative with sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal blood pressure. Timepoint: each 30 minutes. Method of measurement: quantitative with pressure indicator. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Masoumeh Mirteymori
Ommolbanin hospital
Outcome results
None listed