Multiples Sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: Sensory retraining exercises (4 weeks, 3 days a week, 60 minutes each time) with daily use of gabapentin (300 mg/day) or pregabalin (100 mg/day) for 4 weeks. The in
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years Diagnosis of MS and confirmation of the diagnosis by a neurologist according to McDonald criteria and the patient's medical reports Extended Disability Status Scale (EDSS) score less than 6 Willing and able to comply with the study requirements Self-reported paresthesia symptoms including tingling, prickling, prickling, burning, crawling (like an insect moving across the skin), itching, partial numbness, and any abnormal sensation; score of at least 4 out of 10 on at least one of the symptoms of neuropathy (numbness, tingling, prickling, and any abnormal sensation) on a visual analogue scale in the legs in the past four weeks Balance Disorder Report: The Mini-Balance Evaluation Systems Test (Mini-BESTest) will be used. Absence of MS relapses for at least the past 30 days (defined as episodes of focal neurological impairment lasting more than 24 hours and without an alternative explanation).
Exclusion criteria
Exclusion criteria: Central or peripheral nervous system disorders such as head trauma, stroke, diabetes Presence of any wounds or swelling at the treatment site (legs) Systemic diseases Pregnancy lupus Use of Tricyclic antidepressants and Serotonin-norepinephrine reuptake inhibitors family drugs by patients during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Paresthesia intensity. Timepoint: Before the start of the intervention, immediately after the end of intervention course, 4 weeks after the end of the intervention. Method of measurement: Visual Analog Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Balance. Timepoint: Before the start of the intervention, immediately after the end of intervention course, 4 weeks after the end of the intervention. Method of measurement: Biodex balance SD.;Proprioception. Timepoint: Before the start of the intervention, immediately after the end of intervention course, 4 weeks after the end of the intervention. Method of measurement: Body position sense test.;Two-point discrimination. Timepoint: Before the start of the intervention, immediately after the end of intervention course, 4 weeks after the end of the intervention. Method of measurement: Sliding caliper.;The texture of objects. Timepoint: Before the start of the intervention, immediately after the end of intervention course, 4 weeks after the end of the intervention. Method of measurement: Testing the texture of objects with customized kit.;Quality of life. Timepoint: Before the start of the intervention, immediately after the end of intervention course, 4 weeks after the end of the intervention. Method of measurement: Quality of Life questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh mohamadi
Shiraz University of Medical Sciences
Outcome results
None listed