Colon Cancer. Malignant neoplasm of colon
Conditions
Interventions
Intervention 1: Intervention group: Sensory retraining exercises and duloxetine drug. Intervention 2: Control group: Duloxetine drug.
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 40 years Reporting the presence of symptoms of peripheral neuropathy including pain, numbness, tingling and any abnormal sensations by the patient A score of at least 4 out of 10 in at least one of the symptoms of neuropathy in the numeric rating scale of pain in the hands and feet in the last week Completion of the chemotherapy course of patients at least 3 months and at most 9 months before the start of the study and the existence of life expectancy for at least 6 months
Exclusion criteria
Exclusion criteria: The presence of other types of peripheral neuropathy before the start of chemotherapy The presence of any wound or swelling in the treatment area (hands and feet) Epilepsy or cardiac arrhythmia or the presence of a pacemaker in the patient's heart Suffering from diabetes, hyperthyroidism, kidney failure, hepatitis, AIDS and vitamin B12 deficiency pregnancy Use of drugs such as Gabapentin and Pregabalin by patients during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain or paresthesia intensity. Timepoint: Before the start of the intervention and 28 days and 56 days after the start of the intervention. Method of measurement: VAS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ulnar, median and med. & lat. plantar NCV. Timepoint: Before the start of the intervention and 28 days and 56 days after the start of the intervention. Method of measurement: Electromyography device.;Hand dexterity. Timepoint: before the start of the intervention and 28 days and 56 days after the start of the intervention. Method of measurement: Purdue peg board.;Static balance. Timepoint: before the start of the intervention and 28 days and 56 days after the start of the intervention. Method of measurement: Chronometer.;Quality of life. Timepoint: Before the start of the intervention and 28 days and 56 days after the start of the intervention. Method of measurement: EORTC QLQ_30 questionnare.;Lower limb function. Timepoint: Before the start of the intervention and 28 days and 56 days after the start of the intervention. Method of measurement: TUG test time using chronometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Mohamadi
Shiraz University of Medical Sciences
Outcome results
None listed