The effect of Silybum Marianum on treatment of migraine

The effect of Silybum Marianum on the treatment of patients with migraine headache referred to the clinics of Arak University of Medical Sciences

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016022026667N1

Enrollment

Registered

2016-04-22

Start date

2017-07-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine

Interventions

Intervention 1: The intervention group, in addition to drugs, Livergol tablets 70 mg, twice a day for two months will be given. Intervention 2: ?For the control group, in addition to the medications,

Treatment - Drugs

The intervention group, in addition to drugs, Livergol tablets 70 mg, twice a day for two months will be given.

?For the control group, in addition to the medications, administered twice daily placebo pills for two months, that looks like a tablet of Livergol.

Eligibility

Sex/Gender

All

Age

15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Having a history of migraines for 6 months; Headache frequency by at least three times a month; Age 15 to 50 years; Avoiding the use of prophylactic medication. Exclusion criteria: Unwillingness to continue the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Headache. Timepoint: Before, 30 and 60 dayes after intervention. Method of measurement: Questionnaire of visual analog scale.	—

Secondary

Measure	Time frame
Disability. Timepoint: Before, 30 and 60 dayes after intervention. Method of measurement: Questionnaire of MIDAS.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Jadidi

Arak University of Medical Sciences

jadidi@arakmu.ac.ir+98 86 3417 3508

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026