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The effect and comparison of oral and intravenous Acetaminophen in pain cardiac surgery patients

The effect and comparison of oral and intravenous Acetaminophen in pain control and Consumption opioid in post cardiac surgery patients

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016022026217N2
Enrollment
160
Registered
2016-03-16
Start date
2016-09-06
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary and valvular heart surgery. Other functional disturbances following cardiac surgery

Interventions

Intervention 1: Patients in group A received acetaminophen injection every 6 hours, and if continues pain will be administered pethedine. Intervention 2: Patients in group B if have pain will be recei
Treatment - Drugs
Patients in group A received acetaminophen injection every 6 hours, and if continues pain will be administered pethedine.
Patients in group B if have pain will be received acetaminophen injection, and if continues pain will be administered pethedine.
Patients in group C received oral acetaminophen every 6 hours, and if continues pain will be administered pethedine.
Patients in group D if have pain will be received oral acetaminophen, and if continues pain will be administered pethedine.

Sponsors

Vice Chancellor for research, Lorestan University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: all patients who underwent CABG surgery with or without valve replacement; age older than 18 or less than 65 years; absence of addiction to drugs or alcohol; absence of allergy or hypersensitivity to acetaminophen or narcotics; absence of impaired kidney function (creatinine level Less than 2 milligrams per deciliter); no history of liver failure; no history of sleep apnea. Exclusion criteria: Visual analog scale score is higher than 7 after extubation; not wanting to continue cooperation?; use of narcotic drugs and sedatives during the procedure?; decreased level of consciousness of the patient during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Amount of pain. Timepoint: Minute 0, 20, 80 and 120 after receiving the first dose. Method of measurement: visual analog scale.;The amount of narcotic. Timepoint: 24 hours after receiving the first dose. Method of measurement: Milligrams per kilogram of body weight.

Secondary

MeasureTime frame
The best pattern of use drug on regular basis or on when necessary. Timepoint: 24 hours after receiving the first dose. Method of measurement: Visual anlog scale and milligrams per kilogram of body weight.;Nausea. Timepoint: frequency during the first 24 hours after receiving the first dose. Method of measurement: history taking from patient or nurses.;Vomiting. Timepoint: frequency during the first 24 hours after receiving the first dose. Method of measurement: history taking from patient or nurses.;Need for antiemetics. Timepoint: frequency during the first 24 hours after receiving the first dose. Method of measurement: information taken from patient's records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajad Yarahmadi

Lorestan University Of Medical Sciences

yarahmadi.s@tak.iums.ac.ir+98 66 3322 5655

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026