Nephropathy of Anthracyclins. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: Control group: no treatment. Intervention 2: Intervention group 1: Deferoxamine 10-20 mg/kg. Frequency and route of administration is once per day Iv infusion over 8 hours concomitant
Treatment - Drugs
Intervention group 1: Deferoxamine 10-20 mg/kg. Frequency and route of administration is once per day Iv infusion over 8 hours concomitant with the anthracyclin infusion .
Intervention group 2: Deferoxamine 50 mg/kg. Frequency and route of administration is once per day IV infusion over 8 hours.
Sponsors
Vice chancellor of research, Shiaz Univeisity of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: signing informed consent; male or female aged between 2-18 years at screening; new pediatric cancer patients who are going to receive Anthracyclin drugs as part of their chemotherapy regimen. Exclusion criteria: patients below two years old; patients with previous history of treatment with any kind of chemotherapy or radiotherapy; diagnosis of primary or metastatic renal tumors; patients with congenital or acquired renal problems
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Urea Nitrogen. Timepoint: before and after chemotherapy coarse. Method of measurement: Photometric.;Serum creatinin. Timepoint: before and after chemotherapy coarse. Method of measurement: Photometric.;Urine N-acetyl beta glucoseaminidase. Timepoint: before and after chemotherapy coarse. Method of measurement: N-acetyl-beta-glucosaminidase assay.;Urine creatinin. Timepoint: before and after chemotherapy coarse. Method of measurement: Collection of 24 hours urine.;Urine protein. Timepoint: before and after chemotherapy coarse. Method of measurement: Collection of 24 hours urine.;Micro-albuminuria (Urine albumin-to-creatinine ratio). Timepoint: before and after chemotherapy coarse. Method of measurement: Immuno-turbidimetric.;Nephropathy sign. Timepoint: before and after chemotherapy coarse. Method of measurement: Sonograghy. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Bordbar
Shiraz University of Medical Sciences
Outcome results
None listed