Effect of nigella sativa in the treatment of chronic periodontitis

Evaluation effect of mucoadhesive nigella sativa in the treatment of chronic periodontitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016021826637N1

Enrollment

Registered

2017-02-15

Start date

2016-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group:SRP with Mucoadhesive Locally Delivery Nigella Sativa extract 0.2%. Intervention 2: Intervention group:SRP with Mucoadhesive Locally Delivery Thymoquinone 0.02%. Int

Treatment - Drugs

Placebo

Intervention group:SRP with Mucoadhesive Locally Delivery Nigella Sativa extract 0.2%

Intervention group:SRP with Mucoadhesive Locally Delivery Thymoquinone 0.02%

Control group:SRP with placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patient free from systemic illness; patient who had not taken periodontal therapy in the past 3 month Exlusion criteria: dissatisfaction and inability to comply with the follow-up visit requirments; history of systemic illness; received antioxidants like vitamin C and E or ß-Carotene; pregnant

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Probing pocket depth. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe.;Clinical attachment loss. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe.;Plaque index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: plaque index Silness & Loe.;Gingival Index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Observed.;Bleeding Index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Observed\Bleeding Index Muhlemann.	—

Measure

Time frame

Probing pocket depth. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe.;Clinical attachment loss. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe.;Plaque index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: plaque index Silness & Loe.;Gingival Index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Observed.;Bleeding Index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Observed\Bleeding Index Muhlemann.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mohamad Saleh Yassini

Kermanshah Dentistry School

sms.yassini@kums.ac.irsmsaleh0089@gmail.com+98 83 3722 2400

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026