Malignant neoplasm of lung based on the International Classification of Diseases (ICD)-10 (C34). Malignant neoplasm of bronchus and lung
Conditions
Interventions
Intervention 1: Intervention group: Metformin: Metformin will be started at a daily dose of 500 mg (one 500 mg tablet) in the first week and administered at a daily dose of 1000 mg (Aria, Iran) for 12
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range 18-65 years Diagnosis of Malignant neoplasm of lung based on the International Classification of Diseases (ICD)-10 (C34) Average smoking rate of at least five cigarettes in a day (PCD) for at least one year Avoiding from smoking in the enrolment phase for at least seven days Body mass index (BMI) at the range of 18-35 Not using any psychiatric medication or receiving psychological interventions in the three months that lead up to the study Desire to reduce or stop smoking and obtain informed consent
Exclusion criteria
Exclusion criteria: diagnosis of diabetes mellitus High blood pressure Any condition that may reduce the seizure threshold
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes include cigarette withdrawal syndrome. Timepoint: during the 12-weeks treatment, per week 1 assessment. Method of measurement: Cigarette Withdrawal Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include urinary cotinine levels. Timepoint: During the 12-weeks treatment period, per week assessment. Method of measurement: Gas chromatography–mass spectrometry (GC-MS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBijan Pirnia
Shahid Beheshti University of Medical Sciences
Outcome results
None listed