Awakening from general anethesia.
Conditions
Interventions
Intervention 1: Control group: Single dose IV infusion of 500 milliliters of Normal Saline solution 15 minutes before end of surgery. Intervention 2: Intervention group: Single dose IV infusion of Caf
Placebo
Treatment - Drugs
Control group: Single dose IV infusion of 500 milliliters of Normal Saline solution 15 minutes before end of surgery
Intervention group: Single dose IV infusion of Caffeine Citrate in 500 milliliters of Normal Saline solution 15 minutes before end of surgery
Sponsors
Vice chancellor for research, Urmia University Of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Male and female ASA class I and II patients aged 20 to 50 scheduled for elective laparoscopic cholecystectomy using total intravenous anesthesia(TIVA) Exclusion criteria: Age above 20 and under 50 years old; ASA class >II; opioids, caffeine or caffeine containing drinks use during 8 hours before surgery; history of psychologic disorders, epilepsy, antipsychotic or antiepileptic drugs use; hepatic or cardiac diseases.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time interval between BIS value 80 untill BIS=60 after IV anesthetic infusion. Timepoint: Immediately after stopping IV anesthetic infusion. Method of measurement: Chronometer as second.;The time interval between BIS value 80 untill endotracheal extubation. Timepoint: Immediately after stopping IV anesthetic infusion. Method of measurement: Chronometer as second.;The time interval between BIS value 80 untill Patient's eyes opening. Timepoint: Immediately after stopping IV anesthetic infusion. Method of measurement: Chronometer as second.;Short Orientation Memory Concentration Test Score. Timepoint: 30 minutes after endotracheal extubation. Method of measurement: Short Orientation Memory Concentration Test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting. Timepoint: After end of anesthesia and during stay in recovery unit. Method of measurement: By monitoring of the patient's symptoms and asking.;Mean IV anesthetic infusion dose during anesthesia in intervention and control groups. Timepoint: During maintenance of anesthesia. Method of measurement: Calculating of mean maintenance infusion dose of anesthetics as microgram per kilogram of body weight per minute. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Shahram Shokohi
Urmia University Of Medical Sciences
Outcome results
None listed