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Determination and comparison the effects of intraabdominal pouring of bupivacaine, morphine and dexamethasone on postoperative pain after cesarean section

Determination and comparison of the effects of intraperitoneal bupivacaine, morphine and dexamethasone on postoperative pain in women 20 to 45 years old undergoing elective cesarean section with general anesthesia

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201602167695N7
Enrollment
144
Registered
2016-03-13
Start date
2015-01-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after cesarian section. Other obstetric conditions, not elsewhere classified

Interventions

Intervention 1: At the end of surgery, in the group one, 30 cc of bupivacaine 0.025% was poured into the peritoneum by the surgeon. Intervention 2: At the end of surgery, in the group two, 16 mg of de
Prevention
Placebo
At the end of surgery, in the group one, 30 cc of bupivacaine 0.025% was poured into the peritoneum by the surgeon.
At the end of surgery, in the group two, 16 mg of dexamethasone that was diluted to 30 cc with saline was poured into the peritoneum by the surgeon.
At the end of surgery, in the group three, 5mg of morphine that was diluted to 30 cc with saline was poured into the peritoneum by the surgeon.
At the end of surgery, in the control group, 30 cc of saline was poured into the peritoneum by the surgeon.

Sponsors

Vice Chancellor for research of Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Elective cesarean surgery; ASA class 1 and 2; first or second cesarean section; patients aged 20 to 45 years; the weight of the patient in the range of 60 to 90 kg. Exclusion criteria: The reluctance of patients; emergency cases; hypersensitivity to bupivacaine; dexamethasone and morphine; Patients with chronic pain syndrome and chronic Undertreatment with Nonsteroidal anti-inflammatory drugs; opium addiction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
The severity of pain. Timepoint: Every 2 hours till 6 hours after cesarean section. Method of measurement: Score of Pain according to visual analog scale.;Amount of analgesic consumption. Timepoint: Every 2 hours till 6 hours after cesarean section. Method of measurement: Total dose of administered meperidine (mg).

Secondary

MeasureTime frame
Heart rate. Timepoint: Every 2 hours till 6 hours after cesarean section. Method of measurement: Counting heart rate in1 minute.;Blood pressure. Timepoint: Every 2 hours till 6 hours after cesarean section. Method of measurement: Sphygmomanometer.;Nausea and vomiting. Timepoint: Every 2 hours till 6 hours after cesarean section. Method of measurement: 2 points scale: 1: nausea and vomiting , 2: non.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahere Mahmoody

Koosar hospital

ta.mahmoody@gmail.com+98 28 3323 6380

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026