Condition 1: rectal cancer. Condition 2: radiation injury. Benign neoplasm: Rectum Exposure to ionizing radiation
Conditions
Interventions
Intervention 1: Melatonin capsules containing 20 mg daily administered 1 hour before radiation therapy 5 days a week for 28 days. Intervention 2: Administration of a capsule containing 20 mg per day 5
Prevention
Placebo
Melatonin capsules containing 20 mg daily administered 1 hour before radiation therapy 5 days a week for 28 days
Administration of a capsule containing 20 mg per day 5 days per week wholemeal flour 1 hour before radiation therapy for 28 days.
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 60 patients with rectal cancer; aged 40 to 60 years with radiotherapy and chemotherapy same regime that still have not done surgery Exclusion criteria: patients with autoimmune diseases (purpura); von Willebrand's disease; patients that of aspirin drugs; sulfadiazine; daunorubicin use; individuals who previously had chemotherapy or radiotherapy; people who have a history of depression or suicidal feeling
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombocytopenia. Timepoint: before beginning treatment and at the end of treatment. Method of measurement: CBC. | — |
Secondary
| Measure | Time frame |
|---|---|
| Thrombocytopenia. Timepoint: before beginning treatment and at the end of treatment. Method of measurement: CBC. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasim Kouhi Habibi Dehkordi
Babol University of Medical Sciences
Outcome results
None listed