The influence of some kind of ventilation on the heart and brain and lungs

Comparative Effectiveness Airway pressure release ventilation mode on hemodynamics and oxygenation intracranial pressure and cerebral trauma patients than routine fashion ventilation (Synchronized intermittent mandatory ventilation)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016021426558N1

Enrollment

Registered

2016-06-10

Start date

2015-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head Trauma. Other and unspecified injuries of head

Interventions

Intervention 1: Use Airway pressure release ventilation (APRV) mode for an hour in the intervention group. Intervention 2: Use Synchronized intermittent mandatory ventilation (SIMV) mode for an ho

Treatment - Other

Treatment - Drugs

Use Synchronized intermittent mandatory ventilation (SIMV) mode for an hour in the control group

Use Airway pressure release ventilation (APRV) mode for an hour in the intervention group

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between 18 and 70 years; TBI patients who underwent intubation and mechanical ventilation mode SIMV / PSV (due to intervention of the kind of pressure that fashion should be a routine fashion is also a kind of pressure) are hemodynamic stability (MAP> 70 mm Hg and lasting at least 30 minutes before the start of the study); ALI according to the anesthesiologist and intensive care; GCS <9; lack of chronic obstructive pulmonary disease (COPD), according to the anesthesiologist and intensive care, having Vntryklvstvmy catheters for intracranial pressure monitoring, the patient is RASS of -3.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Oxygenation. Timepoint: Baseline, one hour later. Method of measurement: Arterial blood samples.;Increased Intracranial Pressure. Timepoint: Baseline, one hour later. Method of measurement: ventriclostomy.;Hemodynamic. Timepoint: Baseline, one hour later. Method of measurement: Blood pressure measurement.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Baseline, one hour later. Method of measurement: Blood pressure measurement.;Intracranial pressure. Timepoint: Baseline, one hour later. Method of measurement: ventricolostomy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Safari Beidokhti

Shahrood University of Medical Sciences

safarim2@mums.ac.irmaryamners@gmail.com+98 51 3608 6871

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026