The effect of green coffee extract in the treatment of non-alcoholic fatty liver disease

Effect of green coffee extract supplementation on metabolic status, serum leptin level and anthropometric measurements in patients with non-alcoholic fatty liver disease

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201602113664N17

Enrollment

Registered

2016-04-08

Start date

2016-04-03

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver. Fatty liver

Interventions

Intervention 1: Intervention Group: Intake of Green coffee extract 200 mg capsules two times a day, Prepared by Bonian Salamat Kasra company, for 8 weeks. Intervention 2: Placebo groups: Intake a Pla

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Nonalcoholic fatty liver (observation of liver steatosis on Sonographic image) The age range of 20-50 years in women and 20-60 years in men Body mass index greater than 25 and less than 35 kilograms per Square meters

Exclusion criteria

Exclusion criteria: Alcohol intake Gestation, Lactation, and Menopause Following a weight reducing diet Professional athletes History or current diagnosis of anemia, cardiovascular disease; gastrointestinal disease, diabetes, pulmonary disease, renal disease, acute or chronic liver disorders (Hepatitis A, B, ...), biliary impairments, biliary or kidney stones; autoimmune disease, cancers, Inherited disorders affecting the liver, and other diseases Use of medications such as hepatotoxic drugs, anticoagulant drugs, hormonal drugs (e.g., oral contraceptives and/or estrogen), and consuming dietary supplements such as vitamin A, E, C, and omega-3 three months prior to the study and/or during the study period.

Design outcomes

Primary

Measure	Time frame
Fasting Blood sugar. Timepoint: Baseline and after the intervention. Method of measurement: Spectrophotometery.;Liver Enzymes (Alanine aminotransferase, Aspartate aminotransferase). Timepoint: Baseline and after the intervention. Method of measurement: Spectrophotometery.;Serum leptin level. Timepoint: Baseline and after the intervention. Method of measurement: ELISA.;Liver Echogenicity. Timepoint: Baseline and after the intervention. Method of measurement: Liver sonography.;Body Mass Index. Timepoint: Baseline and after the intervention. Method of measurement: (weight/(Height)2),.;Insulin. Timepoint: Baseline and after the intervention. Method of measurement: ELISA.;Waist Circumference. Timepoint: Baseline and after the intervention. Method of measurement: Cm.;Serum adiponectin level. Timepoint: Baseline and after the intervention. Method of measurement: ELISA.;Oxidative status (TAC, MDA). Timepoint: Baseline and after the intervention. Method of measurement: Biochemical.	—

Measure

Time frame

Fasting Blood sugar. Timepoint: Baseline and after the intervention. Method of measurement: Spectrophotometery.;Liver Enzymes (Alanine aminotransferase, Aspartate aminotransferase). Timepoint: Baseline and after the intervention. Method of measurement: Spectrophotometery.;Serum leptin level. Timepoint: Baseline and after the intervention. Method of measurement: ELISA.;Liver Echogenicity. Timepoint: Baseline and after the intervention. Method of measurement: Liver sonography.;Body Mass Index. Timepoint: Baseline and after the intervention. Method of measurement: (weight/(Height)2),.;Insulin. Timepoint: Baseline and after the intervention. Method of measurement: ELISA.;Waist Circumference. Timepoint: Baseline and after the intervention. Method of measurement: Cm.;Serum adiponectin level. Timepoint: Baseline and after the intervention. Method of measurement: ELISA.;Oxidative status (TAC, MDA). Timepoint: Baseline and after the intervention. Method of measurement: Biochemical.

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Secondary

Measure	Time frame
Systolic and diastolic blood pressure. Timepoint: Beginning and eighth week of the study. Method of measurement: By Mercury Barometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamaneh Hosseinabadi

Nutrition and Food Sciences Faculty, Tabriz University of Medical Sciences

saman7347@gmail.cm+98 41 3335 7581

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026