Examinig the mutual interactions of Genetics, Lifestyle and Anthropometric measurements

Conditions

Obesity. Obesity due to excess calories

Zahra Roumi, Zahra Salimi, Zahra Mahmoudi, Khadijeh Abbasi Mobarakeh, Maryam Ladaninezhad et al. (15 authors)

Endocrinology Diabetes & Metabolism2024-03-312 citations

Changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing an intensive lifestyle intervention and the role of FTO genotype in this interaction.

Doaei S, Kalantari N, Izadi P, Salonurmi T, Mosavi Jarrahi A, Rafieifar S, Azizi Tabesh G, Rahimzadeh G, Gholamalizadeh M, Goodarzi MO.

2019-05-2425 citations

10.1186/s12967-019-1921-4

A complete linkage disequilibrium in a haplotype of three SNPs in Fat Mass and Obesity associated (FTO) gene was strongly associated with anthropometric indices after controlling for calorie intake and physical activity.

Kalantari N, Keshavarz Mohammadi N, Izadi P, Gholamalizadeh M, Doaei S, Doaei S, Eini-Zinab H, Salonurmi T, Rafieifar S, Janipoor R, Azizi Tabesh G.

2018-08-207 citations

10.1186/s12881-018-0664-z

Interventions

Intervention 1: Intervention group: 3 month lifestyle intervention based on Ottawa charter will be performed. The interventions include: healthy policy, create supportive environment, community actio

Lifestyle

Intervention group: 3 month lifestyle intervention based on Ottawa charter will be performed. The interventions include: healthy policy, create supportive environment, community action, development

Control group: Observation

Eligibility

Sex/Gender

Male

Age

12 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Age between 12 to 18 years; Completion the consent forms by student and his parents; Lack of diseases effective on weight and body composition; Lack of use of effective drugs on weight and body composition; Participating in educational, cultural and sportive programs. Exclusion criteria: Get a weight affecting disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
FTO gene expression. Timepoint: Baseline, 3 months after intervention. Method of measurement: Real time RT PCR.;IRX3 gene expression. Timepoint: Baseline, 3 months after intervention. Method of measurement: Real time RT PCR.;Lifestyle. Timepoint: Baseline, 3 months after intervention. Method of measurement: Questionaire.	—

Secondary

Measure	Time frame
BMI. Timepoint: Baseline, 3 month after intervention. Method of measurement: WHO standard charts.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeid Doaei

Shahid Beheshti University of Medical Sciences

sdoaei@sbmu.ac.ir+216 690261

Outcome results

None listed