The effect of Clonidine and Dextromethorphan on cold pain threshold

Assessment the effect of Clonidine and Dextromethorphan on cold pain threshold in healthy volunteers

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016020826447N1

Enrollment

Registered

2016-05-12

Start date

2016-05-14

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The pain induced by cold. Superficial frostbite of wrist and hand

Interventions

All the participants will take Clonidine and Dextromethorphan and Placebo tablets (Considering a 10 day wash-out period for each dose of medication). Clonidine tablet, 0.2 mg single dose, once during

Treatment - Drugs

All the participants will take Clonidine and Dextromethorphan and Placebo tablets (Considering a 10 day wash-out period for each dose of medication). Clonidine tablet, 0.2 mg single dose, once durin

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Complete physical and mental health; Informed consent to participate in the study; 18-45 years of age; No cigarette smoking and coffee use; No history of taking anti depressant and analgesic medications. Exclusion Criteria: Acute or chronic pain; Pregnancy; Gastrointestinal bleeding; Renal or liver disease; Asthma; Diabetes; Hyper tension; Mental and, or neurological disease; Hyper sensitivity to Clonidine and Dextromethorphan.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cold pain threshold. Timepoint: Before interventions, First day(After taking pills available in packet No.1), 11th day(after taking pills available in packet No.2), 21th day(After taking pills available in packet No.3), 31th day(After taking pills available in packet No.4), 41th day(After taking pills available in packet No.5). Method of measurement: The maximum storage time (in minutes) in a mixture of water and ice.	—

Measure

Time frame

Cold pain threshold. Timepoint: Before interventions, First day(After taking pills available in packet No.1), 11th day(after taking pills available in packet No.2), 21th day(After taking pills available in packet No.3), 31th day(After taking pills available in packet No.4), 41th day(After taking pills available in packet No.5). Method of measurement: The maximum storage time (in minutes) in a mixture of water and ice.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPorooshat Nazemi

Tehran University of Medical Sciences

p-nazemi@student.tums.ac.ir+98 910 988 3401

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026