The Evaluation of the effect of Atropine administration on parturients' hemodynamics undergoing cesarean section under spinal anesthesia

The Evaluation of the effect of preoperative(spinal Anesthesia) Atropine administration on maternal hemodynamics and PH of neonatal umbilical cord blood in parturients undergoing cesarean section under spinal anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160208026447N2

Enrollment

Registered

2021-04-07

Start date

2016-03-20

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic changes after spinal anesthesia in elective cesarean section.

Interventions

Intervention 1: Intervention group: Administration of 10 microgram/kg atropine intravenously prior to performing spinal anesthesia. Intervention 2: Control group: administration of normal saline in eq

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pregnant females 18 to 45 years old undergoing cesarean section under spinal anesthesia Pregnant females without cardiac or other systemic diseases Pregnant females who have filled written informed consent to perform spinal anesthesia

Exclusion criteria

Exclusion criteria: disagreement in participating in study any history of cardiac diseases

Design outcomes

Primary

Measure	Time frame
Maternal hemodynamic parameters. Timepoint: After administering Atropine as premedication or normal saline as a placebo the maternal vital signs would be checked and recorded, thereafter spinal anesthesia will be provided, and after repositioning to the supine position the vital signs would be checked instantly and would be repeatedly checked every 3 minutes. After delivery, the Ph of neonatal umbilical cord blood sample would be checked instantly and will be recorded. Method of measurement: Vital signs monitoring system.;Ph of umbilical cord blood sample. Timepoint: After administering Atropine as premedication or normal saline as a placebo the maternal vital signs would be checked and recorded, thereafter spinal anesthesia will be provided, and after repositioning to the supine position the vital signs would be checked instantly and would be repeatedly checked every 3 minutes. After delivery, the Ph of neonatal umbilical cord blood sample would be checked instantly and will be recorded. Method of measurement: Using Blood Gas Analysis.	—

Measure

Time frame

Maternal hemodynamic parameters. Timepoint: After administering Atropine as premedication or normal saline as a placebo the maternal vital signs would be checked and recorded, thereafter spinal anesthesia will be provided, and after repositioning to the supine position the vital signs would be checked instantly and would be repeatedly checked every 3 minutes. After delivery, the Ph of neonatal umbilical cord blood sample would be checked instantly and will be recorded. Method of measurement: Vital signs monitoring system.;Ph of umbilical cord blood sample. Timepoint: After administering Atropine as premedication or normal saline as a placebo the maternal vital signs would be checked and recorded, thereafter spinal anesthesia will be provided, and after repositioning to the supine position the vital signs would be checked instantly and would be repeatedly checked every 3 minutes. After delivery, the Ph of neonatal umbilical cord blood sample would be checked instantly and will be recorded. Method of measurement: Using Blood Gas Analysis.

—

Secondary

Measure	Time frame
The number of drugs used during surgery. Timepoint: At the end of surgery. Method of measurement: the number of drugs used at the end of procedure.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhossein Orandi

Tehran University of Medical Sciences

horandi@sina.tums.ac.ir+98 21 6119 2828

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026