Minocycline effects in patients with traumatic brain injury

Comparison of the effect of minocycline and placebo on brain biomarkers in patients with traumatic brain injury: a randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201602063014N12

Enrollment

Registered

2016-08-11

Start date

2016-07-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head injury. Cerebral contusion, laceration. traumatic intracerebral haemorrhage, Epidural haemorrhage, Extradural haemorrhage (traumatic), Traumatic subdural haemorrhage

Interventions

Intervention 1: Control group: Patients receive 100 milligram oral minocycline capsules after surgery every 12 hours for a week. First dose is prescribed within 12 hours of admission. Intervention 2:

Treatment - Drugs

Placebo

Control group: Patients receive 100 milligram oral minocycline capsules after surgery every 12 hours for a week. First dose is prescribed within 12 hours of admission.

Control group: Patients receive 100 milligram glucose capsules, made by Sari pharmacy facaulty, after surgery every 12 hours for a week. First dose is prescribed within 12 hours of admission.

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: The patients who have surgery within 12 hours after admission? glasgow coma scale less than or equal to 12 Exclusion criteria: Pregnant women and lactating? hypersensitivity to tetracycline and minocycline medicine? history of systemic lupus erythematosus? incidence of pseudomembranous colitis

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
S100B protein. Timepoint: Day 1 (before intervention) , Days 2, 3, 4 (after intervention). Method of measurement: Spectrophotometry kit.;Neuron Specific Enolase (NSE). Timepoint: Day 1 (before intervention), Days 3, 5 (after intervention). Method of measurement: Spectrophotometry kit.	—

Secondary

Measure	Time frame
Length of stay in ICU. Timepoint: Hospitalization period in ICU. Method of measurement: Calculating the number of days.;Glasgow coma scale changes. Timepoint: Hospitalization period in ICU. Method of measurement: GCS quiz.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Neda Koulaeinejad

Mazandaran University Of Medical Sciences

nd.koulaei@gmail.com+98 11 3354 3814

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026