Comparison of the effect of the calcium citrate supplement with normal calcium diet on metabolic risk factors in recurrent calcium stone formers with hyperoxaluria

Comparison of the effect of the calcium citrate supplement with normal calcium diet on metabolic risk factors in recurrent calcium stone formers with hyperoxaluria: a randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160206026406N3

Enrollment

Registered

2019-08-13

Start date

2019-03-21

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent calcium stone formers with hyperoxaluria. Calculus of kidney

Interventions

Intervention 1: Intervention group one: Patients receiving daily 800 mg calcium (in two divided doses with lunch and dinner in the form of calcium citrate) plus a diet containing 200 mg of calcium in

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Recurrent stone former Hyperoxaluria (24hr Urine Oxalate between 40-80 mg) Baseline dietary calcium intake less than 800 mg/day The desire to collaborate in the study

Exclusion criteria

Exclusion criteria: Enteric or primary hyperoxaluria (24 hours urine oxalate more than 80 mg) Taking Thiazides or any medicine that has an effect on calcium metabolism Taking any medicine that has an effect on oxalate metabolism Taking vitamin B6 Hepatitis, diabetes, thyroid diseases, hyperparathyroidism, immunological diseases, cancers, chronic diarrhea, chronic kidney diseases and urinary tract infection Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
24hr Urine Oxalate. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: Enzymatic method.;Calcium oxalate supersaturation. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: Calculation by LITHORISK software.	—

Secondary

Measure	Time frame
Urine pH. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: pH meter.;24 hour urine oxalate. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: Enzymatic method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Tavasoli

Urology and Nephrology Research Center

sanaz.tavasoli@gmail.com+98 21 2256 7222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026