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Effectiveness of vitamin D supplementation on severity of chronic liver disease

Effectiveness of vitamin D supplementation on severity of cirrhosis based on CHILD and MELD scores in patients with decompensate cirrhosis

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016020326342N1
Enrollment
80
Registered
2016-02-28
Start date
2016-03-11
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic liver disease. Chronic passive congestion of liver

Interventions

Intervention 1: Control group: popular drugs using for liver cirrhosis. Intervention 2: Intervention group: popular drugs using for liver cirrhosis and 50000 units of vitamin D on a daily basis for th
Treatment - Drugs
Control group: popular drugs using for liver cirrhosis
Intervention group: popular drugs using for liver cirrhosis and 50000 units of vitamin D on a daily basis for three months

Sponsors

Vice Chancellor for Research, Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 139 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All the decompensated cirrhosis patients (CHILD=7) admitted to hospital or referred to Gastroenterology Clinics; aged more than 18 years; and consent to participate in the study. Exclusion criteria: Human immunodeficiency virus patients; renal failure due to reasons other than liver failure; malabsorption such as chronic diarrhea, celiac, chronic pancreatitis; patients undergoing corticosteroid treatment; pregnancy; and cirrhosis patients secondary to cholestasis such as primary biliary cirrhosis

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Liver function. Timepoint: 3 months after intervention. Method of measurement: MELD scoring system; according to levels of bilirubin and creatinine serum.

Secondary

MeasureTime frame
Liver function. Timepoint: 3 months after intervention. Method of measurement: Child-Pugh scoring system; classifies the severity of liver diseases into five categories.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Ali Abbasi

Mashhad University of Medical Sciences

hoseinabbasi1342@yahoo.com+98 51 3859 1057

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026