Comparison of hemodynamic changes in hypertensive patients after dexmedetomidine and midazolam injection

Comparison of hemodynamic response during anesthesia induction using Dexmedetomidine and Midazolam in hypertensive patients undergoing orthopedic surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160202026328N6

Enrollment

130

Registered

2020-11-22

Start date

2020-11-21

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparison of hemodynamic changes in anesthetized patients with hypertension following dexmedetomidine and midazolam injection.. Other complications of anesthesia

Interventions

Intervention 1: Intervention group1: in the first intervention group, 10 µg / kg dexmedetomidine will be injected 5 minutes before anesthesia. Intervention 2: Intervention group 2: in the second inter

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients 40 to 70 years old Known hypertensive treated patients Candidate for elective orthopedic surgery

Exclusion criteria

Exclusion criteria: Patients treated with psychotic drugs Emergency patients Traumatic patients with heavy bleeding Liver and kidney disorders Patients with ischemic heart disease Patients with severe systemic vascular disease

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Mercury barometer.;Diastolic blood pressure. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Mercury barometer.;Heart rate. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Counting in each minutes.;Saturation of peripheral oxygen. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Via the Pulse Oximeter.	—

Measure

Time frame

Systolic blood pressure. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Mercury barometer.;Diastolic blood pressure. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Mercury barometer.;Heart rate. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Counting in each minutes.;Saturation of peripheral oxygen. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Via the Pulse Oximeter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoud Parish

Tabriz University of Medical Sciences

masoudparish@yahoo.com+98 41 3389 3517

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026