amnestic mild cognitive impairment. Mild cognitive impairment, so stated
Conditions
Interventions
Intervention 1: Intervention group 1: receiving GVS and VR, GVS: Subliminal noisy GVS, 20 min, once a week, three sessions. VR: Cooksey-Cawthorne rehabilitation exercises, 30 min, twice a day for one
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosed with aMCI MMSE test score <21 for participants with primary school education and <23 for participants with a university degree MoCA test score between 19 and 24 Adequate visuomotor coordination based on the standard score (Z Score ± 1) in motor screening task (MOT) test Normal or modified visual acuity or with glasses (20/20) using the Snellen chart in order to correctly diagnose CANTAB test forms Normal hearing ability or corrected hearing loss with hearing aid to hear the stimulus in the force plate test
Exclusion criteria
Exclusion criteria: Color blindness according to Ishihara test for color blindness Neck pain or limitation in neck range of motion Anticholinergic drug consumption (e.g. hyoscine and atropine) consumption Consumption of drugs affecting vestibulo-ocular reflex such as Cinnarizine , betahistine, painkillers, and tranquilizers from 48 hours prior to tests History of orthopedic problems in the last 6 months (lower extremity fractures, dislocation, and pain) Obvious lower extremity deformities such as scoliosis and kyphosis according to observation of a physiotherapist History of rheumatic and/or metabolic diseases History of alcoholism or addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment score. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: Montreal Cognitive Assessment (MoCA).;Learning score. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: Rey Auditory Verbal Learning Test.;Immediate recall score. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: Rey Auditory Verbal Learning Test.;Delayed recall score. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: Rey Auditory Verbal Learning Test.;Percentage of correct answers in pattern recognition memory (PRM). Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: CANTAB test.;Response latency in Delayed Matching to Sample. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: CANTAB test.;Percentage of correct selection in Delayed Matching to Sample. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: CANTAB test.;Percentage of errors in Paired Associates Learning. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: CANTAB test.;Spatial Span length. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: CANTAB test.;Vestibulo-ocular reflex gain. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: video head impulse test (vHIT).;Percentage of overt saccades. Timepoint: Before, immediately after the end of the intervention period, and one month later. Method of measurement: video head impulse test (vHIT).;Percentage of covert saccades. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMansoureh Adel Ghahraman
Tehran University of Medical Sciences
Outcome results
None listed