Investigating the effect of Albumin on urine output, using it with lasix and mannitol in ICU patients with oliguria

A clinical trial of comparing the effect of Albumin administration on urine output when using with lasix and mannitol with using lasix and mannitol without Albumin in oliguric patients in ICU

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016013010741N3

Enrollment

100

Registered

2016-04-28

Start date

2015-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal failure. Acute renal failure, unspecified

Interventions

Intervention 1: In intervention group in addition to mannitol and lasix (400 mg lasix plus 100 ml mannitol 20% administering 1 mg/kg/h for 2 consecutive days), albumin (one vial of albumin 20% in 1 li

Treatment - Drugs

In intervention group in addition to mannitol and lasix (400 mg lasix plus 100 ml mannitol 20% administering 1 mg/kg/h for 2 consecutive days), albumin (one vial of albumin 20% in 1 litre normal salin

In control group mannitol and lasix (400 mg lasix plus 100 ml mannitol 20% administering 1 mg/kg/h for 2 consecutive days) is given.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: oliguric patients in ICU; patients with Acute Renal Failure. Exclusion criteria: history of kidney disorders (Cr>1.5mg/dl); proteinuria (urine pr>3.5g/d); kidney disorders like glomerulonephritis and ATN; consumption of furosemide within last two weeks; incorrect urine collection; urine line blockage; low level of albumin (below 4.5 mg/dl).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum BUN level. Timepoint: At the time of admission and then daily. Method of measurement: Blood test.;Serum Cr level. Timepoint: At the time of admission and then daily. Method of measurement: Blood test.	—

Secondary

Measure	Time frame
Daily urine output. Timepoint: During hospital stay daily. Method of measurement: Documentation of collected urine in 24 hours.;Glomerular filtration rate (GFR). Timepoint: Every day during hospital stay. Method of measurement: By means of creatinine clearance equation.;CVP. Timepoint: Before commerce of diuresis and during therapeutic period. Method of measurement: Monitoring device.;Superficial edema. Timepoint: Before commerce of diuresis and during therapeutic period. Method of measurement: Examination.	—

Measure

Time frame

Daily urine output. Timepoint: During hospital stay daily. Method of measurement: Documentation of collected urine in 24 hours.;Glomerular filtration rate (GFR). Timepoint: Every day during hospital stay. Method of measurement: By means of creatinine clearance equation.;CVP. Timepoint: Before commerce of diuresis and during therapeutic period. Method of measurement: Monitoring device.;Superficial edema. Timepoint: Before commerce of diuresis and during therapeutic period. Method of measurement: Examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMinoo Ghahraman

Kerman University of Medical Sciences

m_ghahraman@kmu.ac.ir+98 34 3223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026