Comparison of induction of anesthesia with midazolam and Sodium Thiopental and Sodium Thiopental alone, in Electroconvulsive therapy

Comparative clinical trial of induction of anesthesia with midazolam and Sodium Thiopental versus Thiopental alone in patients which are candidates for Electroconvulsive therapy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016013010741N2

Enrollment

Registered

2016-02-11

Start date

2015-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent depressive disorder. Recurrent depressive disorder

Interventions

Intervention 1: In group A, Sodium Thiopental (3 mg/Kg-IV) is injected for induction of anesthesia. Intervention 2: in group B, patients receive intravenous Sodium Thiopental (1.5 mg/Kg) and midazolam

Treatment - Drugs

In group A, Sodium Thiopental (3 mg/Kg-IV) is injected for induction of anesthesia

in group B, patients receive intravenous Sodium Thiopental (1.5 mg/Kg) and midazolam (2.5 mg)

Eligibility

Sex/Gender

All

Age

17 Years to 139 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with major depression; age over 18 year. Exclusion criteria: air way obstruction; obesity; somnolence; kidney and hepatic failure; muscle weakness; severe asthma; all ECT contraindications; patient's discontent.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Seizure duration. Timepoint: after giving shock. Method of measurement: Chronometer.;Recovery duration. Timepoint: after giving shock. Method of measurement: Chronometer.;Anesthesia duration. Timepoint: after giving shock. Method of measurement: Chronometer.	—

Secondary

Measure	Time frame
Vital sign. Timepoint: during the session. Method of measurement: monitoring device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaha Mehrabi

Kerman University of Medical Sciences

s.mehrabi8912@gmail.com+98 34 3223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026