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The effect of L-arginine in fetuses with intrauterine growth restriction

The effect of L-arginine in fetuses with intrauterine growth restriction, on Doppler ultrasound and fetal biometry indices and infant complications

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160130026260N5
Enrollment
48
Registered
2024-10-29
Start date
2024-11-05
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intrauterine growth restriction. Maternal care for other known or suspected poor fetal growth, unspecified trimester, not applicable or unspecified

Interventions

Intervention 1: Intervention group: mothers will take L-arginine tablets daily with a dose of 3 grams for 21 days. Intervention 2: Control group:mothers will receive daily placebo for 21 days in the f

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Diagnosis of IUGR in mothers using ultrasound and biometry

Exclusion criteria

Exclusion criteria: Medical illness such as diabetes, chronic kidney failure, heart disease, severe anemia Pregnant women with preeclampsia Fetal abnormality Smoking History of allergy to products

Design outcomes

Primary

MeasureTime frame
Doppler sonography. Timepoint: Doppler ultrasound of every two weeks until delivery. Method of measurement: ultrasound.;Sono biometric examination. Timepoint: Sonobiometry of every two weeks until delivery. Method of measurement: Sonography.;Examining complications of thenewborn. Timepoint: Examining newborn complications at birth. Method of measurement: Examining complications of the baby using blood tests and expert examination.

Secondary

MeasureTime frame
Baby's birth weightApgar scoreNICU admission ratePresence of respiratory distress syndromePresence of intracranial bleedingGestational ageCa, FBS, IGF1 and ALP blood factors of the newbornInfant mortality rateFBS mother. Timepoint: All variables are checked at the time of delivery of the mother and the birth of the baby. Method of measurement: Using blood tests and gynecologist examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Shaghayegh Moradi Alamdarloo

Shiraz University of Medical Sciences

shaghayeghmoradi84@gmail.com+98 71 3647 9830

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026