Liver transplantation. Surgical operation with transplant of whole organ
Conditions
Interventions
Intervention 1: Each patient in the intervention group , will received 1.5 gram magnesium sulfate that will be diluted with normal saline up to 50 ml with 50 ml syringe with B label that will be in
Treatment - Drugs
Placebo
Each patient in the intervention group , will received 1.5 gram magnesium sulfate that will be diluted with normal saline up to 50 ml with 50 ml syringe with B label that will be infused intravenou
Each patient in the control group, will receive 50 ml normal saline in 50 ml syringe with A label that will be infused intravenously in 5 minutes.
Sponsors
Vice-Chancellery of Research and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The eligible participants were all patients with end stage liver disease aged between 18 and 60 years old, who were candidates for orthotopic liver transplantation under general anesthesia. Exclusion criteria were: having a history of hepatorenal syndrome types ? and ??; baseline serum potassium >6 meq/l; ejection fraction <60% and cirrhotic cardiomyopathy and patients with INR <1.5.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the coagulation profiles on rotational thromboelastometry (ROTEM) system. Timepoint: First time, before magnesium sulfate infusion and induction of anesthesia and second time, after magnesium sulfate infusion just before surgical incision. Method of measurement: By rotational thromboelastometry (ROTEM) system. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of the serum magnesium level. Timepoint: First time, before magnesium sulfate infusion and induction of anesthesia and second time, after magnesium sulfate infusion just before surgical incision. Method of measurement: In the lab by special kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Ali Sahmeddini
Shiraz University Of Medical Sciences
Outcome results
None listed