Comparison of honey and chlorhexidine mouthwashes on the Patients' oral care in ICU

A Comparative effectiveness of honey 12.5% and chlorhexidine 0.2% mouthwash on the oropharyngeal bacterial colonization in mechanically ventilated Patients in ICU: A randomized control trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016012412257N4

Enrollment

Registered

2016-07-13

Start date

2013-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: oropharyngeal colonization. Condition 2: oropharyngeal colonization. Condition 3: oropharyngeal colonization. Condition 4: oropharyngeal colonization. Bacterial pneumonia, not elsewhere classified Pneumonia due to Klebsiella pneumoniae Pneumonia due to Pseudomonas Pneumonia due to staphylococcus

Interventions

Intervention 1: Oral rinse with 12.5% honey solution will be done twice a day (8AM-8PM) with a sterile technique and during complete 4 days by two trained nurses. Intervention 2: Oral rinse with 0.2%

Prevention

Oral rinse with 12.5% honey solution will be done twice a day (8AM-8PM) with a sterile technique and during complete 4 days by two trained nurses.

Oral rinse with 0.2% chlorhexidine solution will be done twice a day (8AM-8PM) with a sterile technique and during complete 4 days by two trained nurses.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 18-65 years, New patients will admit to the ICU with an endotracheal tube intubation and mechanical ventilation undergo less than 12 hours previously, and have at least 4 days of mechanical ventilation. Exclusion criteria: Re-intubation and Re-admission to the ICU; transfer from another ICU; patients with pneumonitis and other systemic infections; a confirmed diagnosis of lung cancer; a evident signs of airway aspiration; a diagnosed thrombocytopenia (platelet count less than 40 and/or a INR>2 or other coagulopathy); anticoagulant therapy;a confirmed diagnosis of immunosuppression; high FBS, a known hypersensitivity to CHX and honey and other complication related to mouthwash solution used to in this study; leukopenia, HIV; pregnant women; organ transplant patients; oral mucositis; advanced periodontal disease; long term steroid therapy; Oral and maxillofacial surgery; extensive burns; contraindication for semi fowlers' position; absence of inform consent.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Oropharyngeal colonization. Timepoint: befor intervention, 48 and 96 hours after intervention. Method of measurement: blood agar and EMB medium.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad Ramezani-Badr

Zanjan University of Medical Sciences

ramazanibadr@zums.ac.irramezanibadr@gmail.com+98 24 3527 9412

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026