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The effect of olive oil in the treatment of non-alcoholic fatty liver disease

Compare the effect of olive oil and sunflower oil on insulin resistance and oxidative stress and inflammatory markers in overweight patients with nonalcoholic fatty liver

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016011825957N2
Enrollment
80
Registered
2016-02-09
Start date
2015-11-03
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver. Nonalcoholic fatty liver disease (NAFLD)

Interventions

Intervention 1: The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive olive oil. Diet and recommendations are presented separately for e
Treatment - Other
Treatment - Drugs
The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive olive oil. Diet and recommendations are presented separately for each person. The
The intervention group consisted of 40 patients. Randomly placed in this group. 20 grams per day for 3 months receive sunflower oil. Diet and recommendations are presented separately for each person.

Sponsors

Oil Version Factory
Lead Sponsor
School feeding
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: having NAFLD by medical diagnosis (using ultrasound); BMI = 25 and above; willingness to participate in the study, the absence of diabetes mellitus type 2;heart disease; cardiovascular and liver disease (cirrhosis, liver disease Alcohol, viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, biliary obstruction, liver damage induced by drugs hereditary Hemochromatosis, sclerosis cholangitis and antitrypsin deficiency of a-a-1);other serious diseases such as cancer; kidney failure and celiac disease, etc); lack of pregnancy ;lactation; lack of drugs that are causing fatty liver (methotrexate, tamoxifen, Valproate, etc.); avoiding the use of any type of lipid lowering agents (atorvastatin, lovastatin, pravastatin, etc.); fibrates (gemfibrozil, fenofibrate); lack of malnutrition; have no special diets such as vegan and vegetarian; not drinking alcohol and having over 18 years of age. Exclusion criteria: non-compliance with recommended diet for more than 15 days over 3 months; acute or infectious disease; hospitalization or in cases where the criteria mentioned is.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Insulin resistance index. Timepoint: The beginning and end of the study. Method of measurement: blood test.;TNF-Alpha. Timepoint: Before the intervention, after intervention. Method of measurement: blood test.;Oxidative stress index. Timepoint: Before the intervention, after intervention. Method of measurement: blood test.

Secondary

MeasureTime frame
BMI. Timepoint: Beginning of the study and end of each month. Method of measurement: Balance-Meter.;Changes in body composition (fat and muscle mass). Timepoint: Before the intervention, after the intervention. Method of measurement: BIA devices.;The degree of fatty liver. Timepoint: Before the intervention, after the intervention. Method of measurement: Ultrasound.;Waist Circomfrance. Timepoint: Beginning of the study and end of each month. Method of measurement: Meter.;Blood pressure. Timepoint: Beginning of the study and end of each month. Method of measurement: Barometr.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDoctor M. Akhlaghi

Shiraz University Of Medical Sciences

shahlarezaei13932014@gmail.com+98 71 3725 1005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026